Strain Information
Name | JPS844 View On Wormbase |
---|---|
Species | C. elegans |
Genotype | vxIs824; vxIs591. |
Description | vxIs824 [rab-3p::ND18ApoE4::unc-54 3'UTR + myo-2p::mCherry::unc-54 3'UTR]. vxIs591 [tph-1p::GFP::unc-54 3'UTR]. Integrated transgene driving expression of human APOE4 throughout the nervous system; induces age-related neurodegeneration of HSNs and bag-of-worms in up to 60% of D3 adult worms. GFP expression in all serotonergic neurons. Reference: Sae-Lee et al. G3 (Bethesda) 2020 Aug 5;10(8):2851-2861. PMID: 32580938 |
Mutagen | No mutagen |
Outcrossed | x1 |
Made by | Wisath Sae-Lee |
Laboratory | JPS |
Reference | Sae-Lee et al. (2020) APP-induced patterned neurodegeneration is exacerbated by APOE4 in Caenorhabditis elegans. G3 10(8): 2851-2861. doi:10.1534/g3.120.401486 |
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