Strain Information
| Name | JPS725 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | ced-6(n1813) III; vxEx725. |
| Description | vxEx725 [egl-1p::mCherry::egl-1(G55E, F65D)::egl-1 3'UTR + gcy-32p::GFP::unc-54 3'UTR + unc-122p::GFP]. Pick animals with GFP expression in coelomocytes to maintain. mCherry-tagged EGL-1 visible in URX adult neurons and apoptotic cells. G55E and F65D mutations in the BH3-only region to abolish mCherry::EGL-1 function in inducing cell death. Reference: Wu Z, et al. Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2407909122. doi: 10.1073/pnas.2407909122. PMID: 39786930. |
| Mutagen | N/A |
| Outcrossed | x0 |
| Made by | Jesse Cohn |
| Laboratory | JPS |
| Reference | Wu, Z., Cardona, E.A., Cohn, J., Pierce, J.T. (2025). Nonapoptotic role of EGL-1 in exopher production and neuronal health in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2407909122. doi: 10.1073/pnas.2407909122. Epub 2025 Jan 9. PMID: 39786930 |
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