Strain Information
| Name | CVB96 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | siss-1(csn20) IV. |
| Description | siss-1(csn20) animals are defective in stress-induced sleep (SIS) with no other obvious defects in development or behavior. csn20 is a Cys-to-Tyr substitution in the third Cys residue of the EGF motif of SISS-1 (a.k.a. IGEG-1). csn20 phenocopies the deletion allele ve532, indicating that the EGF domain of SISS-1 is functional. Reference: Hill AJ, et al. Nat Commun 15, 10886. doi: 10.1038/s41467-024-55252-4. PMID: 39738055. |
| Mutagen | EMS |
| Outcrossed | x3 |
| Made by | Bryan Robinson |
| Laboratory | CVB |
| Reference | Hill AJ, Robinson B, Jones JG, Sternberg PW & Van Buskirk C (2024). Sleep drive is coupled to tissue damage via shedding of Caenorhabditis elegans EGFR ligand SISS-1. Nat Commun 15, 10886. doi: 10.1038/s41467-024-55252-4 |
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