Strain Information
| Name | COP1880 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | unc-68(knu766) V. |
| Description | The UNC-68a G350R missense mutation (knu766) corresponds to a human myopathic variant, RyR1:p.G341R. Subtle effects on locomotion, and altered response to halothane and aldicarb. This strain replaces COP1879, in which the targeted missense mutation has reportedly reverted back to wild type (AGA codon back to GGA). Reference: Graham B, et al. Front. Genet. 2020; 11:37. doi: 10.3389/fgene.2020.00037 PMID: 32174957 |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x0 |
| Made by | Brittany Graham |
| Laboratory | UL |
| Reference | PMID: 32174957 |
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