Strain Information

Name AUM1535   View On Wormbase
Species C. elegans
Genotypedrsh-1(viz43)/tmC18[dpy-5(tmIs1200[myo-2p::mVenus])] I.
Description[D943G] substitution mutation in conserved residue within RNAse III domain. Balancer marked with myo-2p::Venus. Pick fertile wild-type (non-Dpy) Venus+ to maintain. drsh-1(viz43) homozygous animals display heterochronic phenotypes beginning at L3/L4 molt and typically burst at the vulva in L4. Heterozygotes are wild-type with pharyngeal Venus fluorescence, and segregate Venus+ heterozygotes, non-Venus viz-43 homozygotes, and Dpy Venus+ tmC18 homozygotes. Reference: Barish S, et al. Human Mol Genet. 2022 Aug 25;31(17):2934-2950. doi: 10.1093/hmg/ddac085. PMID: 35405010.
Made byJ. H. Seemann
Laboratory AUM
Reference The microRNA processor DROSHA is a candidate gene for a severe progressive neurological disorder. Barish S., et al. Human Mol Genet. 2022 Aug 25;31(17) DOI: 10.1093/hmg/ddac085
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