Strain Information
| Name | AUM1535 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | drsh-1(viz43)/tmC18[dpy-5(tmIs1200[myo-2p::mVenus])] I. |
| Description | [D943G] substitution mutation in conserved residue within RNAse III domain. Balancer marked with myo-2p::Venus. Pick fertile wild-type (non-Dpy) Venus+ to maintain. drsh-1(viz43) homozygous animals display heterochronic phenotypes beginning at L3/L4 molt and typically burst at the vulva in L4. Heterozygotes are wild-type with pharyngeal Venus fluorescence, and segregate Venus+ heterozygotes, non-Venus viz-43 homozygotes, and Dpy Venus+ tmC18 homozygotes. Reference: Barish S, et al. Human Mol Genet. 2022 Aug 25;31(17):2934-2950. doi: 10.1093/hmg/ddac085. PMID: 35405010. |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x5 |
| Made by | J. H. Seemann |
| Laboratory | AUM |
| Reference | The microRNA processor DROSHA is a candidate gene for a severe progressive neurological disorder. Barish S., et al. Human Mol Genet. 2022 Aug 25;31(17) DOI: 10.1093/hmg/ddac085 |
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