Laboratory Information

NameNWG View on WormBase
Allele designationcrk
HeadNathan Goerhing
Institution The Francis Crick Institute, London, UK
Address 1 Midland Road
SW523
London NW1 1AT
United Kingdom
Gene classes

Strains contributed by this laboratory

Strain Genotype Species Description
NWG285 lgl-1(crk66[lgl-1::GFP]) X. C. elegans GFP tag inserted into endgonenous lgl-1 locus. LGL-1::GFP expressed throughout the worm at all developmental stages. Reference: Rodrigues NTL, et al. Development. 2022 Jul 15;149(14):dev200545. PMID: 35713287
NWG316 pkc-3(crk77[I331A,T394A]) II; par-2(it328[gfp::par-2]) III. C. elegans GFP tag inserted into endgonenous par-2 locus in an analogue-sensitive background. pkc-3(crk77[I331A,T394A]) is a CRISPR-engineered analog-sensitive allele containing both I331A (gatekeeper site) and T394A (suppressor site) mutations, allowing rapid and reversible chemical inhibition of PKC-3 activity. Reference: Ng K, et al. (2022). An analog sensitive allele permits rapid and reversible chemical inhibition of PKC-3 activity in C. elegans. Reference: Ng K, et al. microPublication Biology. 10.17912/micropub.biology.000610
This laboratory hasn't submitted any alleles to the CGC.