Laboratory Information
| Name | ZH View on WormBase |
|---|---|
| Allele designation | en |
| Head | Zheng Zhou |
| Institution | Baylor College of Medicine, Houston, TX |
| Address | Room 322B Mailstop 125 One Baylor PLaza Houston 77030 United States |
| Gene classes | ctns hgrs |
Strains contributed by this laboratory
| Strain | Genotype | Species | Description |
|---|---|---|---|
| MT11068 | ced-12(n3261) I. | C. elegans | Defects in engulfment, persistent cell coprses observed in embyros, larvae, and adult hermaphrodite gonads. Distal tip cell migration defects. |
| ZH1963 | enIs59 I; unc-76(e911) V. | C. elegans | enIs59 [ced-1p::2xFYVE::GFP + unc-76(+)] I. ced-1p::2xFYVE::GFP is a phosphainositol PtdIns(3)P reporter expressed in engulfing cells for assaying cell corpse clearance and other membrane trafficking events. GFP expression from enIs59 is relatively low and causes the least deleterious effects to worm development. Reference: Lu N, et al. PLoS Biol. 2012 Jan;10(1):e1001245. PMID: 22272187 |
| ZH231 | enIs7 X. | C. elegans | enIs7 [ced-1p::ced-1::GFP + unc-76(+)] X. GFP marker for cell corpses. Reference: Lu N, et al. Methods Mol Biol 2009;559, 357-370. PMID: 19609769 |
| ZH2486 | enIs74 II; unc-76(e911) V. | C. elegans | enIs74 [mec-7p::GFP + dyn-1p::mfg-e8::mCherry + unc-76(+)] II. mec-7p::GFP labels touch neurons. MFG-E8::mCherry reporter binds exposed phosphatidylserine (PS) “eat me” signal on the surface of apoptotic or necrotic cells, providing a useful marker for identifying apoptotic or necrotic cells. Reference: Furuta Y, et al. PLoS Genet. 2021 Feb 11;17(2):e1009066. |
| ZH382 | unc-108(n3263) I. | C. elegans | Recessive Unc. Recessive apoptotic cell removal defect. Recessive phagosome maturation defect (inefficient and prolonged phagosome maturation process in embryos). Reference: Mangahas PM, Yu X, and Zhou Z. J Cell Biol. 2008 Jan 28;180(2):357-73. |
This laboratory hasn't submitted any alleles to the CGC.