Laboratory Information
| Name | ZD View on WormBase |
|---|---|
| Allele designation | qd |
| Head | Dennis H Kim |
| Institution | Boston Children's Hospital, Harvard Medical School |
| Address | Division of Infectious Diseases Boston Children's Hospital, Mail stop BCH 3103 300 Longwood Ave. Boston 02115 United States |
| Website | http://www.childrenshospital.org/research/researchers/k/dennis-kim |
| Gene classes | erp hecw gpap |
Strains contributed by this laboratory
| Strain | Genotype | Species | Description |
|---|---|---|---|
| AU78 | agIs219 III. | C. elegans | agIs219 [T24B8.5p::GFP::unc-54 3' UTR + ttx-3p::GFP::unc-54 3' UTR] III. References: Shivers RP, et al. PLoS Genet. 2010 Apr 1;6(4):e1000892. Shivers RP, et al. Cell Host Microbe. 2009 Oct 22;6(4):321-30. |
| ZD101 | tir-1(qd4) III. | C. elegans | Enhanced pathogen susceptibility. Egg laying in response to food is defective. Reference: Shivers RP et al., (2009) Cell Host Microbe 6:321-30. |
| ZD1258 | eif-3.L(qd310) II. | C. elegans | C17G10.9 Increased lifespan and enhanced resistance to endoplasmic reticulum (ER) stress, independent of IRE-1-XBP-1, ATF-6, and PEK-1. Reference: Cattie DJ, et al. PLoS Genet. 2016 Sep 30;12(9):e1006326. |
| ZD1866 | eif-2a(qd338) I. | C. elegans | Y37E3.10. qd338 disrupts Ser49 phosphorylation site; suppresses daf-28(sa191) constitutive dauer entry phenotype. Reference: Kulalert W, et al. Genetics 2017. In press. |
| ZD193 | sek-1(km4) X; qdEx4. | C. elegans | qdEx4 [ges-1p::sek-1(cDNA)::GFP::unc-54-3' UTR + myo-2p::mStrawberry::unc-54-3' UTR]. Array rescues sek-1 in the intestine. References: Shivers RP, et al. Cell Host Microbe. 2009 Oct 22;6(4):321-30. |
| ZD2005 | eif-2Ba(qd335) III. | C. elegans | ZK1098.4. qd335 suppresses daf-28(sa191) constitutive dauer entry phenotype. Reference: Kulalert W, et al. Genetics 2017. In press. |
| ZD202 | sek-1(km4) X; qdEx8. | C. elegans | qdEx8 [unc-119p::sek-1(cDNA)::GFP::unc-54-3' UTR + myo-2p::mStrawberry::unc-54-3' UTR]. Array rescues sek-1 in neurons. References: Shivers RP, et al. Cell Host Microbe. 2009 Oct 22;6(4):321-30. |
| ZD318 | agIs219 atf-7(qd22qd130) III. | C. elegans | agIs219 [T24B8.5p::GFP::unc-54-3' UTR + ttx-3p::GFP::unc-54-3' UTR] III. qd130 suppresses increased pathogen susceptibiliy (Esp) of atf-7(qd22). References: Shivers RP, et al. PLoS Genet. 2010 Apr 1;6(4):e1000892. |
| ZD326 | agIs219 atf-7(qd22qd130) III; pmk-1(km25) IV. | C. elegans | agIs219 [T24B8.5p::GFP::unc-54-3' UTR + ttx-3p::GFP::unc-54-3' UTR] III. atf-7(qd22 qd130) suppresses increased pathogen susceptibiliy (Esp) of pmk-1(km25). References: Shivers RP, et al. PLoS Genet. 2010 Apr 1;6(4):e1000892. |
| ZD340 | agIs219 atf-7(qd22qd130) III; sek-1(km4) X. | C. elegans | agIs219 [T24B8.5p::GFP::unc-54-3' UTR + ttx-3p::GFP::unc-54-3' UTR] III. atf-7(qd22 qd130) suppresses increased pathogen susceptibiliy (Esp) of sek-1(km4). References: Shivers RP, et al. PLoS Genet. 2010 Apr 1;6(4):e1000892. |
| ZD39 | agIs219 III; pmk-1(km25) IV. | C. elegans | agIs219 [T24B8.5p::GFP::unc-54-3' UTR + ttx-3p::GFP::unc-54-3' UTR] III. Intestinal GFP expression from agIs219 is abolished by km25. References: Shivers RP, et al. PLoS Genet. 2010 Apr 1;6(4):e1000892. Shivers RP, et al. Cell Host Microbe. 2009 Oct 22;6(4):321-30. |
| ZD442 | agIs219 atf-7(qd22) III. | C. elegans | agIs219 [T24B8.5p::GFP::unc-54-3' UTR + ttx-3p::GFP::unc-54-3' UTR] III. Enhanced susceptibility to pathogens. References: Shivers RP, et al. PLoS Genet. 2010 Apr 1;6(4):e1000892. Shivers RP, et al. Cell Host Microbe. 2009 Oct 22;6(4):321-30. |
| ZD500 | hecw-1(ok1347) III. | C. elegans | Pathogen avoidance phenotype. Defective nose touch response. |
| ZD891 | agIs219 III; eif-3.K(qd213) V. | C. elegans | agIs219 [T24B8.5p::GFP::unc-54-3' UTR + ttx-3p::GFP::unc-54-3' UTR] III. T16G1.11 Increased lifespan and enhanced resistance to endoplasmic reticulum (ER) stress, independent of IRE-1-XBP-1, ATF-6, and PEK-1. Reference: Cattie DJ, et al. PLoS Genet. 2016 Sep 30;12(9):e1006326. |
Alleles contributed by this laboratory
| Allele | Type | DNA Change | Protein Change |
|---|---|---|---|
| qd4 | Allele | deletion | |
| qd22 | Allele | substitution |