Laboratory Information

NameXMN View on WormBase
Allele designationbgg
HeadBrock Grill
InstitutionSeattle Children's Research Institute
Address 1900 9th Ave
Grill Lab - JMB10
Seattle 98101
United States
Gene classes ppm 

Strains contributed by this laboratory

Strain Genotype Species Description
XMN1208 goa-1(bgg44[G42R]) I. C. elegans Maintain at 20 C; sick at 23C. goa-1(bgg44[G42R]) replicates a human GNA01 disorder-associated mutation. The GNA01 disorder-associated G42R mutation functions as dominant negative allele in heterozygotes, and loss of function when homozygotes are evaluated in locomotion and aldicarb assays. Hypersensitive to aldicarb: hyperactive waveforms on plates and continuous hyperactivity in automated locomotion assays performed in liquid. Reference: Wang D, et al. Hum Mol Genet. 2021 Sep 11;ddab235. doi: 10.1093/hmg/ddab235. PMID: 34508586
XMN1209 goa-1(bgg45[G203R]) I C. elegans Maintain at 20 C; sick at 23C. goa-1(bgg45[G203R]) replicates a human GNA01 disorder-associated mutation. The GNA01 disorder-associated G203R mutation functions as loss of function when homozygotes are evaluated in locomotion and aldicarb assays. Hypersensitive to aldicarb: hyperactive waveforms on plates and continuous hyperactivity in automated locomotion assays performed in liquid. Reference: Wang D, et al. Hum Mol Genet. 2021 Sep 11;ddab235. doi: 10.1093/hmg/ddab235. PMID: 34508586
XMN1210 goa-1(bgg46[R209C]) I. C. elegans Maintain at 20 C; sick at 23C. goa-1(bgg46[R209C]) replicates a human GNA01 disorder-associated mutation. The GNA01 disorder-associated R209C mutation functions as dominant negative allele in heterozygotes, and loss of function when homozygotes are evaluated in locomotion and aldicarb assays. Hypersensitive to aldicarb: hyperactive waveforms on plates and continuous hyperactivity in automated locomotion assays performed in liquid. Reference: Wang D, et al. Hum Mol Genet. 2021 Sep 11;ddab235. doi: 10.1093/hmg/ddab235. PMID: 34508586
This laboratory hasn't submitted any alleles to the CGC.