Laboratory Information

NameNB View on WormBase
Allele designationyk
HeadHyeon-Sook Koo
InstitutionYonsei University, Seoul, Korea
Address Yonsei Univ., College of Life Science & Biotechnology,
Dept. of Biochemistry
50 Yonsei-ro, Seodaemun-ku
Seoul 03722
Korea, Republic of
Website http://web.yonsei.ac.kr/kooh/
Gene classes dic  dna  fnci  fncm  immt  jhdm  rcq 

Strains contributed by this laboratory

Strain Genotype Species Description
NB105 fcd-2(tm1298) IV. C. elegans Homozygotes are viable, but are hypersensitive to DNA crosslinks.
NB131 wrn-1(gk99)/mIn1[dpy-10(e128) mIs14(GFP)] II; exo-1(tm1842) III. C. elegans Heterozygotes (wrn-1/mIn1;exo-1) are WT and GFP+. mIn1 homozygotes (mIn1;exo-1) are Dpy and GFP+. wrn-1;exo-1 homozygotes are non-GFP.  Reference: Ryu, J.S. and Koo, H.S. (2017). FEBS Lett.
NB240 hsr-9(ok759) I. C. elegans Reduced apoptosis after gamma-ray treatment compared to N2. Reference: Ryu JS, et al; PLoS One. (In Press).
NB245 aak-1(tm1944) III; aak-2(gt33) X. C. elegans Hypersensitive to oxidative stress; more sensitive to the stress than either of the cognate single mutants. Parental aak-1(tm1944) strain outcrossed 8 times; parental aak-2(gt33) strain outcrossed 3 times. Reference: Lee H, et al. J Biol Chem. 2008 May 30;283(22):14988-93.
NB320 dna-2(jh115)/mIn1[dpy-10(e128) mIs14(GFP)] II. C. elegans Heterozygotes are WT and GFP+. mIn1 homozygotes are Dpy and GFP+. dna-2 homozygotes are non-GFP.  Reference: Lee, K.H., Lee, M.H., Lee, T.H., Han, J.W., Park, Y.J., Ahnn, J., Seo, Y.S. and Koo, H.S. (2003). Mol Cell 15, 81-6.
NB327 ints-6(tm1615) IV/nT1 [qIs51] (IV;V). C. elegans Heterozygotes are WT with pharyngeal GFP signal, and segregate WT GFP+, arrested nT1 aneuploids, and non-GFP dic-1 homozygotes. dic-1(tm1615) homozygotes arrest at the L3 larval stage. ints-6 previously known as dic-1.
NB353 hsr-9(ttTi14815) I. C. elegans Reduced apoptosis after gamma-ray treatment compared to N2. Reference: Ryu JS, et al; PLoS One. (In Press).
NB390 hsr-9(ok759) I; brc-1(tm1145) III. C. elegans Reduced apoptosis after gamma-ray treatment compared to N2. Double mutant exhibits hypersensitivity to gamma rays similar to brc-1(tm1145) alone. Reference: Ryu JS, et al; PLoS One. (In Press).
NB514 exo-1(tm1842) III; parg-2(ok980) IV. C. elegans Double mutant is less sensitive to ionizing radiation than the parg-2(ok980) single mutant, but as sensitive as the exo-1(tm1842) single mutant. Parental parg-2(ok980) strain outcrossed 6 times; parental exo-1(tm1842) strain outcrossed 4 times. Reference: Bae W, et al. Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans. The FEBS Journal, In press.
NB515 polq-1(tm2572) III; parg-2(ok980) IV. C. elegans Hypersensitivity to ionizing radiation due to the parg-2(ok980) mutation is rescued by the polq-1(tm2572) mutation.  The double mutant is as sensitive as the wild-type to ionizing radiation. Parental parg-2(ok980) strain outcrossed 6 times; parental polq-1(tm2572) strain outcrossed 5 times. Reference: Bae W, et al. Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans. The FEBS Journal, In press.
This laboratory hasn't submitted any alleles to the CGC.