Laboratory Information

NameMAV View on WormBase
Allele designationsrh
HeadMarc Vermulst
InstitutionUniversity of Southern California, Los Angeles CA
Address University of Southern California
Leonard Davis School of Gerontology
3715 McClintock Ave
Los Angeles 90089-0191
United States
Gene classes

Strains contributed by this laboratory

Strain Genotype Species Description
MV1 polg-1(srh1)/mnC1[dpy-10(e128) unc-52(e444) nIs190 let-?] II C. elegans [This strain is not available to order. The strain accumulates mitochondrial defects even as a het, and is not suitable for long-term propagation.] The homozygous polg-1(srh1) allele is sterile and the worms are non fluorescent. The homozygous balancer strain is lethal. The heterozygote strain has a fluorescent pharyngeal bulb. Pick heterozygotes to maintain the strain. Over multiple generations the strain accumulates mitochondrial DNA mutations. It is best to outcross the polg-1(srh1) allele using males into a hermaphrodite that has wildtype mitochondrial DNA. The behavioral phenotypes and mitochondrial dysfunction starts around 15 generations of carrying the mutant polymerase and plateaus at around 30 generations.
This laboratory hasn't submitted any alleles to the CGC.