Laboratory Information
| Name | LG View on WormBase |
|---|---|
| Allele designation | ge |
| Head | Leonard P Guarente |
| Institution | MIT, Cambridge MA, USA |
| Address | M.I.T. Biology, 68-280 31 Ames St Cambridge 02139 United States |
| Gene classes | sir |
Strains contributed by this laboratory
| Strain | Genotype | Species | Description |
|---|---|---|---|
| LG269 | geIs3 dyf-x(ge1) I. | C. elegans | geIs3 [sir-2.1(+) + rol-6(su1006)]. Rollers. This strain replaces LG100. Reference: Viswanathan M, Guarente L. Nature. 2011 Sep 21;477(7365):E1-2. |
| LG326 | skn-1(zu169) IV; geIs7. | C. elegans | geIs7 [skn-1b::GFP]. Reference: Nature (2007) 447(7144):545-9. |
| LG331 | lin-35(n745) I; geIs7. | C. elegans | geIs7 [skn-1b::GFP]. Reference: Nature (2007) 447(7144):545-9. |
| LG333 | skn-1(zu135) IV; geIs7. | C. elegans | geIs7 [skn-1b::GFP + rol-6(su1006)]. Rollers. Reference: Nature (2007) 447(7144):545-9. |
| LG340 | skn-1(zu135) IV/nT1 [qIs51] (IV;V); geEx1. | C. elegans | geEx1 [gpa-4p::skn-1b::GFP + rol-6(su1006)]. Rollers. Pick Rolling GFP+ and check for correct segregation of progeny to maintain. skn-1 heterozygotes are WT with pharyngeal GFP signal, and segregate WT GFP, arrested nT1[qIs51] aneuploids, and non-GFP skn-1 homozygotes (early arrest). Homozygous nT1[qIs51] inviable. Reference: Nature (2007) 447(7144):545-9. |
| LG344 | geIs8. | C. elegans | geIs8 [gpa-4p::skn-1b::GFP + rol-6(su1006)]. Reference: Nature (2007) 447(7144):545-9. |
| LG345 | geIs9. | C. elegans | geIs9 [gpa-4p::skn-1b::GFP + rol-6(su1006)]. Reference: Nature (2007) 447(7144):545-9. |
| LG348 | skn-1(zu135) IV/nT1 [qIs51] (IV;V); geIs9. | C. elegans | geIs9 [gpa-4p::skn-1b::GFP + rol-6(su1006)]. Rollers. Heterozygotes are rollers with pharyngeal GFP signal, and segregate GFP+ rollers, arrested nT1[qIs51] aneuploids, and non-GFP skn-1 homozygotes (early arrest). Homozygous nT1[qIs51] inviable. Pick GFP+ rollers and check for correct segregation of progeny to maintain. skn-1 mutants are maternal-effect lethal and must be maintained as balanced heterozygotes. Reference: Bishop & Guarente, Nature (2007) 447(7144):545-9. |
| LG349 | geIs10. | C. elegans | geIs10 [ges-1p(long)::skn-1c::GFP + rol-6(su1006)]. Reference: Nature (2007) 447(7144):545-9. |
| LG357 | skn-1(zu135) IV/nT1 [qIs51] (IV;V); geIs10. | C. elegans | geIs10 [ges-1p(long)::skn-1c::GFP + rol-6(su1006)]. Rollers. Heterozygotes are rollers with pharyngeal GFP signal, and segregate GFP+ rollers, arrested nT1[qIs51] aneuploids, and non-GFP skn-1 homozygotes (early arrest). Homozygous nT1[qIs51] inviable. Pick GFP+ rollers and check for correct segregation of progeny to maintain. skn-1 mutants are maternal-effect lethal and must be maintained as balanced heterozygotes. Reference: Bishop & Guarente, Nature (2007) 447(7144):545-9. |
| LG394 | geIs3 I. | C. elegans | geIs3 [sir-2.1(+) + rol-6(su1006)]. Rollers. This strain contains the transgene from LG100 crossed away from a linked dyf mutaion. Reference: Reference: Viswanathan M, Guarente L. Nature. 2011 Sep 21;477(7365):E1-2. |
| LG398 | geIs101. | C. elegans | geIs101 [rol-6(su1006)]. Rollers. Reference: Viswanathan M, Guarente L. Nature. 2011 Sep 21;477(7365):E1-2. |
| LG433 | dyf-x(ge1) I. | C. elegans | Reference: Viswanathan M, Guarente L. Nature. 2011 Sep 21;477(7365):E1-2. |
| NL3908 | unc-119(ed3) III; pkIs1641. | C. elegans | pkIs1641[unc-119(+)]. Non-Unc strain. |
| NL3909 | unc-119(ed3) III; pkIs1642. | C. elegans | pkIs1642[unc-119(+) + R11A8.5(+) + sir-2.1(+)]. Non-Unc strain. |
Alleles contributed by this laboratory
| Allele | Type | DNA Change | Protein Change |
|---|---|---|---|
| ge1 | Allele |