Laboratory Information
| Name | JY View on WormBase |
|---|---|
| Allele designation | yz |
| Head | Sze, Ji Ying |
| Institution | Albert Einstein College of Medicine, Bronx, NY |
| Address | Dept of Molecular Pharmacology
Albert Einstein College of Medicine
202 Golding building
1300 Morris Park Ave.
Bronx, NY 10461 |
| Website | http://www.einstein.yu.edu/home/faculty/profile.asp?id=10562&O=1 |
| Gene classes | nss |
Strains contributed by this laboratory
| Strain | Genotype | Species | Description |
|---|---|---|---|
| GR1321 | tph-1(mg280) cam-1(vs166) II. | C. elegans | Slow pumping. Egg laying defective. Low frequency of dauer formation. Residual serotonin immunoreactivity, rare and very faint (<1% of NSMs) in most stages, but nearly 100% of CP neurons in adult males show faint to moderate serotonin immunoreactivity. Males mate quite well (E. Hare and C. Loer). Some phenotypic defects originally attributed to mg280 in this strain are likely due to vs166. vs166 is a large deletion (approx. 9.8kb) in the cam-1 gene; flanking sequences are: 5'-gctactggtaaataaggtaa-3' and 5'-atgcttttaaagtttatatt-3' (Edith Myers, personal commnication). See MT15434 for a strain carrying mg280 without the cam-1 mutation. |
| JY190 | osm-9(yz6) IV. | C. elegans | Downregulation of tph-1::GFP expression in the ADF neurons. CORRECTION: The yz6 allele had been erroneously listed as y26 in our database. |
| JY243 | ocr-2(yz5) IV. | C. elegans | Downregulation of tph-1::GFP expression in the ADF neurons. |
| JY359 | lim-4(yz12) X. | C. elegans | Down regulation of tph-1::GFP expression in the ADF neurons. |
Alleles contributed by this laboratory
| Allele | Type | DNA Change | Protein Change |
|---|---|---|---|
| yz6 | Allele | substitution | nonsense |
| yz5 | Allele | substitution | |
| yz12 | Allele | deletion |