Laboratory Information

NameAM View on WormBase
Allele designationrm
HeadRichard I. Morimoto
InstitutionNorthwestern University, Evanston, IL
Address Morimoto Laboratory
Northwestern University
2205 Tech Drive, Hogan 2-100
Evanston 60208
United States
Website http://www.biochem.northwestern.edu/morimoto/index.html
Gene classes bag  chn  osr  phi  tspr  ttc 

Strains contributed by this laboratory

Strain Genotype Species Description
AM1 osr-1(rm1) I. C. elegans Osmotic stress resistant. Received new stock May 7, 2008.
AM101 rmIs110. C. elegans rmIs110 [F25B3.3p::Q40::YFP]. Pan-neuronal YFP expression. Reference: Gidalevitz T, et al., Science. 2006 Mar 10;311(5766):1471-4.
AM134 rmIs126. C. elegans rmIs126 [unc-54p::Q0::YFP]. Diffuse distribution of Q0::YFP throughout the body-wall muscle cells. [NOTE: This strain is not currently available to order. Strain was reported as incorrect; apparently carries 20Q transgene. No replacement currently available.]
AM138 rmIs130 II. C. elegans rmIs130 [unc-54p::Q24::YFP]. Diffuse distribution of Q24::YFP throughout the body-wall muscle cells.
AM140 rmIs132 I. C. elegans rmIs132 [unc-54p::Q35::YFP]. AM140 animals show a Q35::YFP progressive transition from soluble to aggregated as they age.
AM141 rmIs133. C. elegans rmIs133 [unc-54p::Q40::YFP]. AM141 animals show a soluble Q40::YFP distribution in body wall muscle cells immediately after hatching. As these worms age the rapid formation of foci is observed. When they reach adulthood, AM141 animals show an entirely Q40::YFP aggregated phenotype.
AM263 rmIs175. C. elegans rmIs175 [unc-54p::Hsa-sod-1 (WT)::YFP]. Array encodes wild-type human SOD-1. YFP expression in body wall muscle. Array is prone to silencing; maintain by picking worms displaying typical aggregation patterns. Reference: Gidalevitz T, et al., PLoS Genet. 2009 Mar;5(3):e1000399.
AM44 rmIs190. C. elegans rmIs190 [F25B3.3p::Q67::CFP]. Pan-neuronal CFP expression.
AM49 rmIs172. C. elegans rmIs172 [F25B3.3p::Q19::CFP]. Pan-neuronal CFP expression. Reference: Gidalevitz T, et al., Science. 2006 Mar 10;311(5766):1471-4.
AM725 rmIs290. C. elegans rmIs290 [unc-54p::Hsa-sod-1 (127X)::YFP]. Array encodes mutated form of human SOD-1. YFP expression in body wall muscle. Array is prone to silencing; maintain by picking worms displaying typical aggregation patterns. Reference: Gidalevitz T, et al., PLoS Genet. 2009 Mar;5(3):e1000399.

Alleles contributed by this laboratory

Allele Type DNA Change Protein Change
rm1 Allele substitution splice_site