Laboratory Information
| Name | AG View on WormBase |
|---|---|
| Allele designation | av |
| Head | Andy Golden |
| Institution | NIDDK/NIH |
| Address | 8 Center Dr. Bldg. 8, Rm. 323 Bethesda 20892 United States |
| Website | http://www2.niddk.nih.gov/NIDDKLabs/IntramuralFaculty/GoldenAndy |
| Gene classes | air apc mat plk sdhb sdhd som wee fitm |
Strains contributed by this laboratory
| Strain | Genotype | Species | Description |
|---|---|---|---|
| AG150 | apc-1(ar104)/unc-4(e120) bli-1(e769) II. | C. elegans | Heterozygotes are WT and segregate WT, UncBli, and Steriles which have an everted vulva. ar104 previously called evl-22 and mat-2. |
| AG151 | cdc-25.1(nr2036)/dpy-5(e61) unc-13(e450) I. | C. elegans | Heterozygotes are WT and segregate WT, DpyUncs and adult steriles. Original deletion from Axys Pharmaceuticals. |
| AG152 | unc-85(e1414) bli-2(e768) dpy-10(e128) II. | C. elegans | Unc and Dpy. Not Blistered: dpy-10 suppresses the appearance of the blisters. |
| AG165 | san-1(av31) unc-13(e450) I. | C. elegans | Unc. Reduced brood size. Larval lethal, larval arrest. Steriles. Bursts at vulva. Can be maintained as a homozygote. |
| AG166 | mdf-2(av16) unc-17(e245) IV. | C. elegans | Reduced brood size. Reduced hatching. Slow growth. Larval lethal. Larval arrest. Bursts at vulva. Suppresses the mat-3 one-cell arrest at 25C. |
| AG168 | fzy-1(av15) unc-4(e120) II. | C. elegans | Unc. Gain-of-function allele of fzy-1. |
| AG171 | mdf-1(av19) unc-42(e270) V. | C. elegans | Unc. Previously called AG164 by the CGC. |
| AG226 | rol-6(e187) unc-4 (e120)/mnC1 [dpy-10(e128) unc-52(e444) nIs190 let-?] II; him-8(e1489) IV. | C. elegans | nIs190 [myo-2::GFP]. Him. Heterozygotes are wild-type GFP+ and segregate WT GFP+ heterozygotes, Rol Uncs, dead embryos, and males. nIs190 [myo-2::GFP] integrated in or near mnC1. Approx 0.5% recombination seen between nIs190 and mnC1. Fails to complemement all markers on mnC1. |
| AG247 | tyms-1(tm2429) I/hT2 [bli-4(e937) let-?(q782) qIs48] (I;III). | C. elegans | Homozygous lethal deletion balanced by bli-4- and GFP-marked translocation. Heterozygotes are WT with pharyngeal GFP signal, and segregate WT GFP+, arrested hT2 aneuploids, and non-GFP tm2429 homozygotes (embryonic lethal). Homozygous hT2[bli-4 let-? qIs48] inviable. Pick WT GFP+ and check for correct segregation of progeny to maintain. Reference: Jaramillo-Lambert A, et al. G3 (2015). |
| AG248 | mus-101(tm1761) I/hT2 [bli-4(e937) let-?(q782) qIs48] (I;III). | C. elegans | Homozygous lethal deletion balanced by bli-4- and GFP-marked translocation. Heterozygotes are WT with pharyngeal GFP signal, and segregate WT GFP+, arrested hT2 aneuploids, and non-GFP tm1761 homozygotes (embryonic lethal). Homozygous hT2[bli-4 let-? qIs48] inviable. Pick WT GFP+ and check for correct segregation of progeny to maintain. Reference: Jaramillo-Lambert A, et al. G3 (2015). |
| AG50 | daf-7(e1372) dpy-1(e1) III. | C. elegans | Maintain at 15C. Temperature-sensitive dauer constitutive: 100% dauers at 25C, leaky at 20C. Dpy. Crowds. |
| COP262 | unc-119(ed3) III; knuSi221. | C. elegans | knuSi221 [fib-1p::fib-1(genomic)::eGFP::fib-1 3' UTR + unc-119(+)]. Single copy insertion. fib-1 promoter, genomic sequence, and 3'UTR was inserted into pCFJ151 (ttTi5606) targeting vector and inserted into ttTi5605. Allen AK, Nesmith JE, and A Golden. 2014 G3:4(12)2329-43. |
Alleles contributed by this laboratory
| Allele | Type | DNA Change | Protein Change |
|---|---|---|---|
| av31 | Allele | ||
| av16 | Allele | ||
| av15 | Allele | ||
| av19 | Allele | substitution |