Variation Information: q35

Nameq35 View on WormBase
Species C. elegans
Genetic positionIII:0.16 +/- 0.000 cM
Genomic positionIII: 9098913..9098913
Protein change Substitution

Strains carrying this variation

Strain Genotype Species Description
JK590 glp-1(q35)/eT1 III; him-5(e1490)/eT1 V. C. elegans Heterozygotes are wild-type and segregate wild-type heterozygotes, glp-1(q35) homozygotes (Muv steriles), eT1 homozygotes (Unc-36), and males. glp-1(q35) has a semi-dominant multi-vulva phenotype as well as the loss-of-function Glp phenotype (sterility and embryonic lethality). The q35 mutation is a nonsense mutation that eliminates 122 C-terminal amino acids including a PEST sequence. The C terminus was thought to contain a negative regulatory domain that inactivates glp-1 in the VPCs; the inappropriate glp-1(q35) activity can substitute for lin-12 vulval fate determination. References: Austin J & Kimble J. Cell. 1987 Nov 20;51(4):589-99. Mango S, et al. Nature. 1991 Aug 29;352(6338):811-5.