Variation Information: we11
| Name | we11 View on WormBase |
|---|---|
| Species | C. elegans |
| Genetic position | IV:5.91 +/- 0.000 cM |
| Genomic position | IV: 12409318..12409318 |
| Protein change | Substitution |
Strains carrying this variation
| Strain | Genotype | Species | Description |
|---|---|---|---|
| CA1117 | dsb-1(we11) IV/nT1[unc-?(n754) let-?] (IV;V). | C. elegans | Heterozygotes are Unc and segregate Uncs, dead eggs, and non-Uncs (dsb-1 homozygotes), which produce 99% inviable embryos due to meiotic nondisjunction. Pick Unc to maintain and check for correct segregation of progeny. we11 is a TCA to TAA nonsense mutation in the dsb-1 coding sequence that introduces a premature stop after leucine 96. Reference: Stamper EL, et al. PLoS Genet. 2013;9(8):e1003679. |