Variation Information: e1457

Namee1457 View on WormBase
Species C. elegans
Genetic positionII:0.59 +/- 0.000 cM
Genomic positionII: 7860778..7860778
Protein changeT09A5.10 T09A5.10 Substitution

Strains carrying this variation

Strain Genotype Species Description
SV46 lin-5(e1457)/mnC1 [dpy-10(e128) unc-52(e444)] II. C. elegans Heterozygotes are WT and segregate WT, Stu and DpyUncs. e1457 is a strong loss-of-function or null allele. Molecular lesion: G to E at position 40. DNA replication continues in the absence of mitosis. Mutants enter mitotis at the normal time and form bipolar spindles, but fail chromosome alignment at the metaphase plate, sister chromatid separation and cytokinesis.