Variation Information: n1046

Namen1046 View on WormBase
Species C. elegans
Genetic positionIV:5.21 +/- 0.000 cM
Genomic positionIV: 11691040..11691040
Protein changeZK792.6 Substitution

Strains carrying this variation

Strain Genotype Species Description
MH1131 soc-2(ku167) let-60(n1046) IV. C. elegans Less than 5% Muv. Previously called sur-8(ku167).
MH231 let-60(n1046) IV; ksr-1(ku68) X. C. elegans Semi-dominant suppressor of let-60(n1046). Strong reduction of function mutation. At 20C: <1% Muv, 24% Egl, 6% larval lethal, and SM migration defects.
MH538 mek-2(ku114) I; let-60(n1046) IV. C. elegans
MT2124 let-60(n1046) IV. C. elegans Non-lethal let-60 allele, multivulva phenotype (93% penetrance). Semi-Dominant (17% of hets are Muv). Amber suppressible. Non-null. PKA lin-34. See WBPaper00006902: strain probably carries a side mutation(s) that impairs chemotaxis to the odorant isoamyl alcohol.
MT4244 unc-24(e138) let-60(n1046) IV. C. elegans Unc. Muv (sd, gf).
MT4574 let-60(n1531)/let-60(n1046) unc-22(e66) IV. C. elegans Heterozygotes are WT and segregate WT, MuvUnc (n1046 e66) and n1531 homozygotes whose phenotypes range from a few dead larva to sterile adults. The normal larval lethality of n1531/n1531 is suppressed by the maternal contribution of n1046. n1046 is semi-dominant.
MT4725 let-60(n1046) dpy-20(e1282) IV. C. elegans Dpy (ts). Muv (sd, gf).
MT6378 lin-45(n2506) let-60(n1046) IV. C. elegans n2506 suppresses n1046.
MT6399 let-60(n1046) IV; cdf-1(n2527) X. C. elegans cdf-1(n2527) suppresses the let-60(n1046gf) Muv phenotype from 95% Muv to <5% Muv. Suppression is weakly semi-dominant.
MT6400 let-60(n1046) IV; cgr-1(n2528) X. C. elegans Low penetrance Muv (<5%). Due to variable penetrance larval lethal phenotype at 15C, maintain at 20C.
NH2267 let-60(n1046) IV; egl-15(n1454) X. C. elegans Unc and scrawny, but viable. Egl. Class II egl-15 mutation. Lethality suppressed by let-60.
PJ1062 let-60(n1046) IV; ccIs55 V. C. elegans ccIs55 [unc-54::lacZ + sup-7(st5)] V.
PS4627 let-60(n1046) unc-31(e169) V/nT1 [let(m435)] (IV;V). C. elegans Maintain by picking WT. Segregates Muv Unc (let-60 unc-31 homozygotes), wild-type heterozygotes and dead eggs. Reference: Moghal N, Sternberg PW. Development. 2003 Jan;130(1):57-69.
PS468 let-60(sy100) dpy-20(e1282)/let-60(n1046) unc-22(s7) IV; him-5(e1490) V. C. elegans Heterozygotes are weak Muv and segregate weak Muv, Muv Twitchers, and Dpy Vuls whose progeny are larval lethal. sy100 is a dominant negative allele of let-60. n1046 is a gain-of-function allele of let-60. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
SD366 mpk-1(n2521) III; let-60(n1046) IV. C. elegans Less than 5% Muv animals.
WU684 let-60(n1046) IV; cgr-1(am114) X. C. elegans Low penetrance Muv (<1%). Slow growing at 20C. 75% larval lethality at 15C. Maintain at 20C.