| MH1131 |
soc-2(ku167) let-60(n1046) IV. |
C. elegans |
Less than 5% Muv. Previously called sur-8(ku167). |
| MH231 |
let-60(n1046) IV; ksr-1(ku68) X. |
C. elegans |
Semi-dominant suppressor of let-60(n1046). Strong reduction of function mutation. At 20C: <1% Muv, 24% Egl, 6% larval lethal, and SM migration defects. |
| MH538 |
mek-2(ku114) I; let-60(n1046) IV. |
C. elegans |
|
| MT2124 |
let-60(n1046) IV. |
C. elegans |
Non-lethal let-60 allele, multivulva phenotype (93% penetrance). Semi-Dominant (17% of hets are Muv). Amber suppressible. Non-null. PKA lin-34. See WBPaper00006902: strain probably carries a side mutation(s) that impairs chemotaxis to the odorant isoamyl alcohol. |
| MT4244 |
unc-24(e138) let-60(n1046) IV. |
C. elegans |
Unc. Muv (sd, gf). |
| MT4574 |
let-60(n1531)/let-60(n1046) unc-22(e66) IV. |
C. elegans |
Heterozygotes are WT and segregate WT, MuvUnc (n1046 e66) and n1531 homozygotes whose phenotypes range from a few dead larva to sterile adults. The normal larval lethality of n1531/n1531 is suppressed by the maternal contribution of n1046. n1046 is semi-dominant. |
| MT4725 |
let-60(n1046) dpy-20(e1282) IV. |
C. elegans |
Dpy (ts). Muv (sd, gf). |
| MT6378 |
lin-45(n2506) let-60(n1046) IV. |
C. elegans |
n2506 suppresses n1046. |
| MT6399 |
let-60(n1046) IV; cdf-1(n2527) X. |
C. elegans |
cdf-1(n2527) suppresses the let-60(n1046gf) Muv phenotype from 95% Muv to <5% Muv. Suppression is weakly semi-dominant. |
| MT6400 |
let-60(n1046) IV; cgr-1(n2528) X. |
C. elegans |
Low penetrance Muv (<5%). Due to variable penetrance larval lethal phenotype at 15C, maintain at 20C. |
| NH2267 |
let-60(n1046) IV; egl-15(n1454) X. |
C. elegans |
Unc and scrawny, but viable. Egl. Class II egl-15 mutation. Lethality suppressed by let-60. |
| PJ1062 |
let-60(n1046) IV; ccIs55 V. |
C. elegans |
ccIs55 [unc-54::lacZ + sup-7(st5)] V. |
| PS4627 |
let-60(n1046) unc-31(e169) V/nT1 [let(m435)] (IV;V). |
C. elegans |
Maintain by picking WT. Segregates Muv Unc (let-60 unc-31 homozygotes), wild-type heterozygotes and dead eggs. Reference: Moghal N, Sternberg PW. Development. 2003 Jan;130(1):57-69. |
| PS468 |
let-60(sy100) dpy-20(e1282)/let-60(n1046) unc-22(s7) IV; him-5(e1490) V. |
C. elegans |
Heterozygotes are weak Muv and segregate weak Muv, Muv Twitchers, and Dpy Vuls whose progeny are larval lethal. sy100 is a dominant negative allele of let-60. n1046 is a gain-of-function allele of let-60. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects. |
| SD366 |
mpk-1(n2521) III; let-60(n1046) IV. |
C. elegans |
Less than 5% Muv animals. |
| WU684 |
let-60(n1046) IV; cgr-1(am114) X. |
C. elegans |
Low penetrance Muv (<1%). Slow growing at 20C. 75% larval lethality at 15C. Maintain at 20C. |