| MH1131 |
soc-2(ku167) let-60(n1046) IV. |
C. elegans |
Less than 5% Muv. Previously called sur-8(ku167). |
| MH231 |
let-60(n1046) IV; ksr-1(ku68) X. |
C. elegans |
Semi-dominant suppressor of let-60(n1046). Strong reduction of function mutation. At 20C: <1% Muv, 24% Egl, 6% larval lethal, and SM migration defects. |
| MH538 |
mek-2(ku114) I; let-60(n1046) IV. |
C. elegans |
|
| MT2124 |
let-60(n1046) IV. |
C. elegans |
Non-lethal let-60 allele, multivulva phenotype (93% penetrance). Semi-Dominant (17% of hets are Muv). Amber suppressible. Non-null. PKA lin-34. See WBPaper00006902: strain probably carries a side mutation(s) that impairs chemotaxis to the odorant isoamyl alcohol. |
| MT4244 |
unc-24(e138) let-60(n1046) IV. |
C. elegans |
Unc. Muv (sd, gf). |
| MT4574 |
let-60(n1531)/let-60(n1046) unc-22(e66) IV. |
C. elegans |
Heterozygotes are WT and segregate WT, MuvUnc (n1046 e66) and n1531 homozygotes whose phenotypes range from a few dead larva to sterile adults. The normal larval lethality of n1531/n1531 is suppressed by the maternal contribution of n1046. n1046 is semi-dominant. |
| MT4725 |
let-60(n1046) dpy-20(e1282) IV. |
C. elegans |
Dpy (ts). Muv (sd, gf). |
| MT6378 |
lin-45(n2506) let-60(n1046) IV. |
C. elegans |
n2506 suppresses n1046. |
| MT6399 |
let-60(n1046) IV; cdf-1(n2527) X. |
C. elegans |
cdf-1(n2527) suppresses the let-60(n1046gf) Muv phenotype from 95% Muv to <5% Muv. Suppression is weakly semi-dominant. |
| MT6400 |
let-60(n1046) IV; cgr-1(n2528) X. |
C. elegans |
Low penetrance Muv (<5%). Due to variable penetrance larval lethal phenotype at 15C, maintain at 20C. |
| NH2267 |
let-60(n1046) IV; egl-15(n1454) X. |
C. elegans |
Unc and scrawny, but viable. Egl. Class II egl-15 mutation. Lethality suppressed by let-60. |
| PJ1062 |
let-60(n1046) IV; ccIs55 V. |
C. elegans |
ccIs55 [unc-54::lacZ + sup-7(st5)] V. |
| PS4627 |
let-60(n1046) unc-31(e169) V/nT1 [let(m435)] (IV;V). |
C. elegans |
Maintain by picking WT. Segregates Muv Unc (let-60 unc-31 homozygotes), wild-type heterozygotes and dead eggs. Reference: Moghal N, Sternberg PW. Development. 2003 Jan;130(1):57-69. |
| PS468 |
let-60(sy100) dpy-20(e1282)/let-60(n1046) unc-22(s7) IV; him-5(e1490) V. |
C. elegans |
Heterozygotes are weak Muv and segregate weak Muv, Muv Twitchers, and Dpy Vuls whose progeny are larval lethal. sy100 is a dominant negative allele of let-60. n1046 is a gain-of-function allele of let-60. Do not distribute this strain; other labs should request it from the CGC. |
| SD366 |
mpk-1(n2521) III; let-60(n1046) IV. |
C. elegans |
Less than 5% Muv animals. |
| WU684 |
let-60(n1046) IV; cgr-1(am114) X. |
C. elegans |
Low penetrance Muv (<1%). Slow growing at 20C. 75% larval lethality at 15C. Maintain at 20C. |
