Variation Information: e911

Namee911 View on WormBase
Species C. elegans
Genetic positionV:7.32 +/- 0.000 cM
Genomic positionV: 15076958..15076968
Protein changeC01G10.11a C01G10.11b C01G10.11c C01G10.11d C01G10.11f Deletion

Strains carrying this variation

Strain Genotype Species Description
BA585 spe-10(hc104) unc-76(e911) V. C. elegans Unc. Temperature sensitive, maintain at 16C. Average progeny: at 16C= 7 +/- 5; at 25C= 0.1 +/- .1.
BC4586 unc-76(e911) rol-9(sc148)/sC4(s2172) [dpy-21(e428)] V. C. elegans Heterozygotes are WT and segregate WT and Unc Rollers. sC4(s2172) is not viable as a homozygote. As a heterozygote it reduces recombination between unc-76 and rol-9 to 1.8%.
BS518 ozDf1/sdc-3(y52y180) unc-76(e911) V. C. elegans Heterozygotes are slow growing with WT phenotype. Hets segregate more slow growing WT, embryonic lethals (ozDf1/ozDf1) and DpyUncs which are sick and have a maternal effect lethal (none of the offspring from the DpyUncs survive to reproduce). Maintain by picking WT.
CB2065 dpy-11(e224) unc-76(e911) V. C. elegans DpyUnc.
CU6102 skr-1(sm151) I; unc-76(e911) V. C. elegans sm151 is a semi-dominant allele of skr-1. Maintain under normal conditions. Reference: Killian DJ, et al. (2008) Dev Biol. 322(2):322-31.
CU7905 smIs350 IV; unc-76(e911) V. C. elegans smIs350 [hsp-16::mCherry-NLS + tra-2::FLAG(3x) + unc-76(+)] IV. Some sterility. Maintain under normal conditions. Reference: Mapes J, et al. (2010) PNAS In press.
CU9087 unc-76(e911) V; smIs380. C. elegans smIs380 [tra-2::GFP + unc-76(+)]. Some sterility. Maintain under normal conditions. Reference: Mapes J, et al. (2010) PNAS In press.
DA709 +/nT1 IV; sqt-3(sc63) eat-6(ad467) unc-76(e911)/nT1 V. C. elegans Heterozygotes are WT and segregate WT, Vul and Sqt Unc larvae that grow very slowly.
DA869 sqt-3(sc8) lin-25(n545) him-5(e1467) unc-76(e911) V. C. elegans Roller. Unc. Vulvaless. Throws males. sc8 previously called rol-4(sc8).
DR188 daf-11(m47) unc-76(e911) V. C. elegans Temperature sensitive dauer constitutive. Dauer recovery poor at 15C. Unc.
DR96 unc-76(e911) V. C. elegans Coiler Unc. Recessive. Easily scored.
EL129 ego-3(om40) unc-76(e911) V/nT1 [unc-?(n754) let-?] (IV;V). C. elegans Heterozygotes are Unc and segregate additional hets, Unc-76 om40 homozygotes and dead eggs. om40 animals have multiple germline defects.
HS1215 unc-76(e911) V; osEx211. C. elegans osEx211[apr-1::GFP + unc-76(+)]. This strain expresses functional APR-1::GFP driven by the apr-1 promoter. In the seam cells, just prior to the onset of mitosis, APR-1::GFP localizes to the anterior cortex.
HS1257 unc-76(e911) V; osEx219. C. elegans osEx219 [pbrm-1::GFP + unc-76(+)]. Pick wild-type to maintain. GFP expression in most somatic nuclei. Reference: Shibata Y, et al. Dev Biol. 2012 Jan 15;361(2):349-57.
HS1294 unc-76(e911) V; osEx225. C. elegans osEx225 [scm::dsh-2::venus + unc-76(+)]. Pick non-Unc to maintain. Reference: Mizumoto K, Sawa H. Dev Cell. 2007 Feb;12(2):287-99.
HS1325 unc-76(e911) V; osEx229. C. elegans osEx229 [pry-1::GFP + unc-76(+)]. This strain expresses functional pry-1::GFP driven by the pry-1 promoter. In the seam cells, just prior to the onset of mitosis, pry-1::GFP localizes to the anterior cortex.
HS1359 unc-76(e911) V; osEx233. C. elegans osEx233 [scm::mig-5::venus + unc-76(+)]. Pick non-Unc to maintain. Reference: Mizumoto K, Sawa H. Dev Cell. 2007 Feb;12(2):287-99.
HS1380 unc-76(e911) V; osEx240. C. elegans osEx240 [bet-1p::bet-1::GFP + unc-76(+)]. Pick Wild-type (non-Unc) to maintain. GFP expression in most somatic cells. Reference: Shibata Y, et al. Development. 2010 Apr;137(7):1045-53.
HS2329 unc-76(e911) V; osEx397. C. elegans osEx397 [cwn-1p::cwn-1::Venus] Transgene is expressed in tail region. Pick nonUnc to maintain. Reference: Yamamoto et al. PLoS Genet. 2011 Oct;7(10):e1002308.
HS2332 unc-76(e911) V; osEx393. C. elegans osEx393 [cwn-2p::cwn-2::Venus] Transgene is expressed in the pharynx. Pick nonUnc to maintain. Reference: Yamamoto et al. PLoS Genet. 2011 Oct;7(10):e1002308.
HS321 him-5(e1467) unc-76(e911) V; osEx67. C. elegans osEx67 [psa-4::GFP + unc-76(+)]. Maintain by picking non-Unc. Reference: Sawa H, et al. Mol Cell. 2000 Sep;6(3):617-24.
HS325 him-5(e1467) unc-76(e911) V; osEx71. C. elegans osEx71 [psa-1::GFP + unc-76(+)]. Maintain by picking non-Unc. Reference: Sawa H, et al. Mol Cell. 2000 Sep;6(3):617-24.
HS942 unc-76(e911) V; osEx158. C. elegans osEx158 [wrm-1::GFP + unc-76(+)]. Animals with the array are WT and GFP+. Animals which have lost the array are Unc and GFP-.
IA123 cdc-25.1(ij48) I; unc-76(e911) ijIs10 V. C. elegans ijIs10 [cpr-5::GFP::lacZ + unc-76(+)]. Extra intestinal cells.
JR113 sma-1(e30) unc-76(e911) wDf2/sqt-3(sc8) unc-61(e228) V. C. elegans Heterozygotes are WT and segregate WT, RolUncs and dead eggs. Homozygous wDf1 embryos arrest uniformly as unenclosed balls of differentiated cells. wDf2 formerly called zen-1(w1). sc8 previously called rol-4(sc8).
JR41 unc-76(e911) wDf1/unc-61(e228) dpy-21(e428) V. C. elegans Heterozygotes are WT and segregate WT, DpyUncs and dead eggs. Homozygous wDf1 embryos arrest uniformly as unenclosed balls of differentiated cells. wDf1 formerly called zen-1(e2482). 2/02: dpy-21 appears to have been lost from this strain.
ML743 rdy-2(mc40)/sqt-3(sc63) him-5(e1467) unc-76(e911) V. C. elegans Heterozygotes are WT and segregate WT, Rol Uncs, and dead L2 larvae that are translucent and often found away from the bacterial lawn (can be difficult to spot on the lawn).
MT10408 lin-53(n833) I; unc-76(e911) V; lin-15A(n767) X; nEx998. C. elegans nEx998 [lin-53::GFP + unc-76(+)]. Pick non-Unc, non-Muv to maintain.
MT10865 unc-76(e911) V; nEx1039. C. elegans nEx1039 contains [ced-10p::GFP::ced-10 + unc-76(+)]. Maintain at 20 C. Described in Lunquist et al., Development 128, 4475-4488 (2001).
MT2663 sqt-3(sc63) him-5(e1467) egl-1(n986) unc-76(e911) V. C. elegans Dominant Egl. Unc. Dpy (ts). Throws males.
MT3553 egl-43(n997) II; unc-76(e911) V. C. elegans n997: Egl, 5HT-S, IMIP-R.
MT5439 sqt-3(sc8) unc-76(e911) V; lon-2(e678) xol-1(y70) X. C. elegans Roller. Long. Unc. XO Lethal. sc8 previously called rol-4(sc8).
MT6940 dpy-20(e1282) IV; unc-76(e911) V. C. elegans Unc. Temperature sensitive Dpy.
MT9926 efl-1(n3318)/unc-76(e911) dpy-21(e428) V. C. elegans Heterozygotes are WT and segregate WT, UncDpy and Mel. Received new stock from the Horvitz lab 5/04.
OC235 sun-1(bs12) unc-76(e911) V. C. elegans Unc. bs12 mutation causes sublethal defect in attachment of centrosome to the nucleus in early embryos. Viable 15-25 C. Reference: Kemp et al. (2007) Genetics 176:95-113.
SP1493 sma-1(e30) unc-76(e911)/vab-8(e1017) V. C. elegans Heterozygotes are WT and segregate WT, SmaUnc and animals with a posterior half that is thin, pale, uncoordinated.
SS268 dpy-11(e224) mes-4(bn23) unc-76(e911) V/nT1 [unc-?(n754) let-?] (IV;V). C. elegans Heterozygotes are Unc (n754 is a dominant Unc and recessive lethal). Throws DpyUncs which give sterile progeny. The maternal effect sterility is 99% expressed, 100% strict, and is associated with 2% maternal effect embryonic lethality.
TY1077 C25D7.12(y128) unc-76(e911)/sdc-3(y52) unc-76(e911) V; xol-1(y9) X. C. elegans Heterozygotes are Unc and segregate Uncs, Dpy Uncs [C25D7.12(y128) unc-76(e911) homozygotes], and Tra Uncs [sdc-3(y52) unc-76(e911) homozygotes]. Do not distribute this strain; other labs should request it directly from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
TY1388 C25D7.12(y128)/sdc-3(y52) unc-76(e911) V. C. elegans Heterozygotes are WT and segregate WT, Dpys [C25D7.12(y128) homozygotes], and Tra Uncs [sdc-3(y52) unc-76(e911) homozygotes]. Do not distribute this strain; other labs should request it directly from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
TY832 yDf4/dpy-11(e224) unc-76(e911) V. C. elegans Heterozygotes are WT and segregate WT, DpyUnc and dead eggs. Maintain by picking WT.
TY873 yDf6/unc-76(e911) V. C. elegans Heterozygotes are WT and segregate WT, Unc, and dead eggs. Maintain by picking WT.
TY903 yDf7/unc-76(e911) V. C. elegans Heterozygotes are WT and segregate WT, Unc and dead eggs. Maintain by picking WT.
TY956 sdc-3(y132)/unc-76(e911) V. C. elegans Heterozygotes are WT and segregate WT, Unc and Dpy (sdc-3/sdc-3). sdc-3 homozygotes exhibit a strong maternal effect lethality->most progeny from homozygotes arrest as L1 larvae--about 14% escape the lethality and develop into Dpy, Egl hermaphrodites.
VT581 dpy-5(e61) lin-28(n719) I; lin-46(ma164) unc-76(e911) V. C. elegans Dpy Unc. Egl+. lin-46 suppresses precocious Egl- phenotype of lin-28. lin-46 alone makes gaps in adult alae; enhanced at 15C.
XW5399 unc-76(e911) V; qxIs257. C. elegans qxIs257 [ced-1p::nuc-1::mCherry + unc-76(+)]. Integrated nuc-1::mCherry transgene marking lysosomes in epidermal cells. Site of chromosomal integration unknown. Not known if unc-76(e911) is still present in background. Reference: Li Y, et al. J Cell Biol. 2016 Oct 24;215(2):167-185.
XW8056 unc-76(e911) V; qxIs430. C. elegans qxIs430 [scav-3::GFP + unc-76(+)]. Integrated GFP translational fusion transgene marking lysosomes in epithelial cells. Not known if unc-76(e911) is still present in background. Reference: Li Y, et al. J Cell Biol. 2016 Oct 24;215(2):167-185.
ZH1963 enIs59 I; unc-76(e911) V. C. elegans enIs59 [ced-1p::2xFYVE::GFP + unc-76(+)] I. ced-1p::2xFYVE::GFP is a phosphainositol PtdIns(3)P reporter expressed in engulfing cells for assaying cell corpse clearance and other membrane trafficking events. GFP expression from enIs59 is relatively low and causes the least deleterious effects to worm development. Reference: Lu N, et al. PLoS Biol. 2012 Jan;10(1):e1001245. PMID: 22272187
ZH2486 enIs74 II; unc-76(e911) V. C. elegans enIs74 [mec-7p::GFP + dyn-1p::mfg-e8::mCherry + unc-76(+)] II. mec-7p::GFP labels touch neurons. MFG-E8::mCherry reporter binds exposed phosphatidylserine (PS) “eat me” signal on the surface of apoptotic or necrotic cells, providing a useful marker for identifying apoptotic or necrotic cells. Reference: Furuta Y, et al. PLoS Genet. 2021 Feb 11;17(2):e1009066.