Transgene Information

NamedvIs50 View on WormBase
Description[pCL45 (Psnb-1::Abeta 1-42::3' UTR(long) + Pmtl-2::GFP]

Strains carrying this transgene

Strain Genotype Species Description
CL2355 smg-1(cc546) dvIs50 I. C. elegans dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP] I. Maintain at 16C. Pan-neuronal expresion of human Abeta peptide. Constitutive intestinal expression of GFP from marker transgene. Strain shows deficits in chemotaxis, associative learning, and thrashing in liquid. Strain also has incomplete sterility due to germline proliferation defects and embryonic lethality. Maintain at 16 C to reduce selection against transgene, although this does not alter the partial sterility. Reference: Wu Y., et al. J Neurosci. 2006 Dec 13;26(50):13102-13.