| KWN922 |
C. elegans |
rnySi61 *rnySi59 II; otIs730. Show Description
rnySi61 [UPNp::AID::eGFP::TauT4(T231E)::tbb-2 3’UTR + Cbr-unc-119(+) II. otIs730 [UPNp::TIR1::mTur2 + inx-6(prom18)::TagRFP]. Touch response deficit. Phosphomimetic human TauT4(T231E) model. rnySi61 was generated by CRISPR modification of the rnySi59 insertion to introduce the T231E mutation. Transgene expression is driven by the Ultra Pan-Neuronal (UPN) promoter, a synthetic promoter designed to express equally in all neurons. Reference: Carroll TA, et al. J Alzheimers Dis. 2026 Jan;109(1):189-202. doi: 10.1177/13872877251392935. PMID: 41284589.
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