| KWN1020 |
C. elegans |
rnyIs18 II; otIs730. Show Description
rnyIs18 [UPNp::AID::eGFP::tbb-2 3'UTR + unc-119(split) + HygromycinR(+) II. otIs730 [UPNp::TIR1::mTur2 + inx-6(prom18)::TagRFP]. Alzheimer’s Disease model low copy number GFP control strain. Transgene expression is driven by the Ultra Pan-Neuronal (UPN) promoter, a synthetic promoter designed to express equally in all neurons. Reference: Carroll TA, et al. Neurobiol Dis. 2026 Mar 14:222:107350. doi: 10.1016/j.nbd.2026.107350. PMID: 41833859.
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| KWN1021 |
C. elegans |
rnyIs19 II; otIs730. Show Description
rnyIs19 [UPNp::AID::eGFP::tbb-2 3'UTR + unc-119(split) + HygromycinR(+) II. otIs730 [UPNp::TIR1::mTur2 + inx-6(prom18)::TagRFP]. Alzheimer’s Disease model high copy number GFP control strain. Transgene expression is driven by the Ultra Pan-Neuronal (UPN) promoter, a synthetic promoter designed to express equally in all neurons. Reference: Carroll TA, et al. Neurobiol Dis. 2026 Mar 14:222:107350. doi: 10.1016/j.nbd.2026.107350. PMID: 41833859.
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| KWN1022 |
C. elegans |
rnyIs26 II; otIs730. Show Description
rnyIs26 [UPNp::AID::eGFP::TauT4::tbb-2 3'UTR + unc-119(split) + HygromycinR(+) II. otIs730 [UPNp::TIR1::mTur2 + inx-6(prom18)::TagRFP]. Associative memory defect. Reduced brood size. Alzheimer’s Disease model low copy number (level 3) Tau strain. Transgene expression is driven by the Ultra Pan-Neuronal (UPN) promoter, a synthetic promoter designed to express equally in all neurons. Reference: Carroll TA, et al. Neurobiol Dis. 2026 Mar 14:222:107350. doi: 10.1016/j.nbd.2026.107350. PMID: 41833859.
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| KWN1023 |
C. elegans |
rnyIs28 II; otIs730. Show Description
rnyIs28 [UPNp::AID::eGFP::TauT4::tbb-2 3'UTR + unc-119(split) + HygromycinR(+) II. otIs730 [UPNp::TIR1::mTur2 + inx-6(prom18)::TagRFP]. Associative memory defect. Reduced brood size. Alzheimer’s Disease model high copy number (level 7) Tau strain. Transgene expression is driven by the Ultra Pan-Neuronal (UPN) promoter, a synthetic promoter designed to express equally in all neurons. Reference: Carroll TA, et al. Neurobiol Dis. 2026 Mar 14:222:107350. doi: 10.1016/j.nbd.2026.107350. PMID: 41833859.
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| KWN1024 |
C. elegans |
rnyIs38 II; otIs730. Show Description
rnyIs38 [UPNp::AID::eGFP::TauT4(T231E)::tbb-2 3'UTR + unc-119(split) + HygromycinR(+) II. otIs730 [UPNp::TIR1::mTur2 + inx-6(prom18)::TagRFP]. Associative memory defect. Alzheimer’s Disease model low copy number (level 3) Tau(T231E) strain. Transgene expression is driven by the Ultra Pan-Neuronal (UPN) promoter, a synthetic promoter designed to express equally in all neurons. Reference: Carroll TA, et al. Neurobiol Dis. 2026 Mar 14:222:107350. doi: 10.1016/j.nbd.2026.107350. PMID: 41833859.
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| KWN1025 |
C. elegans |
rnyIs40 II; otIs730. Show Description
rnyIs40 [UPNp::AID::eGFP::TauT4(T231E)::tbb-2 3'UTR + unc-119(split) + HygromycinR(+) II. otIs730 [UPNp::TIR1::mTur2 + inx-6(prom18)::TagRFP]. Associative memory defect. Thrashing and touch response defective. Reduced brood size. Alzheimer’s Disease model high copy number (level 7) Tau(T231E) strain. Transgene expression is driven by the Ultra Pan-Neuronal (UPN) promoter, a synthetic promoter designed to express equally in all neurons. Reference: Carroll TA, et al. Neurobiol Dis. 2026 Mar 14:222:107350. doi: 10.1016/j.nbd.2026.107350. PMID: 41833859.
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| KWN921 |
C. elegans |
rnySi58 II; otIs730. Show Description
rnySi58 [UPNp::AID::eGFP::TauT4::tbb-2 3’UTR + Cbr-unc-119(+) II. otIs730 [UPNp::TIR1::mTur2 + inx-6(prom18)::TagRFP]. Human Tau T4 model. Transgene expression is driven by the Ultra Pan-Neuronal (UPN) promoter, a synthetic promoter designed to express equally in all neurons. Reference: Carroll TA, et al. J Alzheimers Dis. 2026 Jan;109(1):189-202. doi: 10.1177/13872877251392935. PMID: 41284589.
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| KWN922 |
C. elegans |
rnySi61 *rnySi59 II; otIs730. Show Description
rnySi61 [UPNp::AID::eGFP::TauT4(T231E)::tbb-2 3’UTR + Cbr-unc-119(+) II. otIs730 [UPNp::TIR1::mTur2 + inx-6(prom18)::TagRFP]. Touch response deficit. Phosphomimetic human TauT4(T231E) model. rnySi61 was generated by CRISPR modification of the rnySi59 insertion to introduce the T231E mutation. Transgene expression is driven by the Ultra Pan-Neuronal (UPN) promoter, a synthetic promoter designed to express equally in all neurons. Reference: Carroll TA, et al. J Alzheimers Dis. 2026 Jan;109(1):189-202. doi: 10.1177/13872877251392935. PMID: 41284589.
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| OH15845 |
C. elegans |
daf-16(ot853[daf-16::mNG::AID*]) I; daf-2(e1370) III; otIs730. Show Description
otIs730 [UPNp::TIR1::mTur2 + inx-6(prom18)::TagRFP]. Temperature sensitive dauer constitutive. Maintain at 15C. UPN (Ultra Pan-Neuronal) promoter contains four short pan-neuronal promoters fused together (unc-11::rgef-1::ehs-1::ric-19). Panneuronal depletion of DAF-16 in the presence of auxin. Reference: Aghayeva et al. PLoS Biol. 2021 Apr 23;19(4):e3001204. doi: 10.1371/journal.pbio.3001204. PMID: 33891586.
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| OH15913 |
C. elegans |
daf-7(e1372) III; daf-12(ot874[daf-12::TagRFP::AID*]) X; otIs730. Show Description
otIs730 [UPN::TIR1::mTur2 + inx-6(prom18)::TagRFP]. Temperature sensitive dauer constitutive. Maintain at 15C. UPN (Ultra Pan-Neuronal) promoter contains four short pan-neuronal promoters fused together (unc-11::rgef-1::ehs-1::ric-19). Panneuronal depletion of DAF-12 in the presence of auxin. Reference: Aghayeva et al. PLoS Biol. 2021 Apr 23;19(4):e3001204. doi: 10.1371/journal.pbio.3001204. PMID: 33891586.
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| OH16508 |
C. elegans |
daf-16(ot975[daf-16::mNeptune2.5::3xFlag::AID*]) I; daf-2(e1370) III; otIs730. Show Description
otIs730 [UPN::TIR1::mTur2 + inx-6(prom18)::TagRFP]. Temperature sensitive dauer constitutive. Maintain at 15C. UPN (Ultra Pan-Neuronal) promoter contains four short pan-neuronal promoters fused together (unc-11::rgef-1::ehs-1::ric-19). Panneuronal depletion of DAF-16 in the presence of auxin. Reference: Aghayeva et al. PLoS Biol. 2021 Apr 23;19(4):e3001204. doi: 10.1371/journal.pbio.3001204. PMID: 33891586.
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