Strain Information

Name XMN1210   View On Wormbase
Species C. elegans
Genotypegoa-1(bgg46[R209C]) I.
DescriptionMaintain at 20 C; sick at 23C. goa-1(bgg46[R209C]) replicates a human GNA01 disorder-associated mutation. The GNA01 disorder-associated R209C mutation functions as dominant negative allele in heterozygotes, and loss of function when homozygotes are evaluated in locomotion and aldicarb assays. Hypersensitive to aldicarb: hyperactive waveforms on plates and continuous hyperactivity in automated locomotion assays performed in liquid. Reference: Wang D, et al. Hum Mol Genet. 2021 Sep 11;ddab235. doi: 10.1093/hmg/ddab235. PMID: 34508586
Mutagen
Outcrossedx0
Made byDandan Wang
Laboratory XMN
Reference Dandan Wang, Maria Dao, Brian S Muntean, Andrew C Giles, Kirill A Martemyanov, Brock Grill, Genetic modeling of GNAO1 disorder delineates mechanisms of Gαo dysfunction, Human Molecular Genetics, 2021;, ddab235, https://doi.org/10.1093/hmg/ddab235
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