Strain Information
| Name | XMN1208 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | goa-1(bgg44[G42R]) I. |
| Description | Maintain at 20 C; sick at 23C. goa-1(bgg44[G42R]) replicates a human GNA01 disorder-associated mutation. The GNA01 disorder-associated G42R mutation functions as dominant negative allele in heterozygotes, and loss of function when homozygotes are evaluated in locomotion and aldicarb assays. Hypersensitive to aldicarb: hyperactive waveforms on plates and continuous hyperactivity in automated locomotion assays performed in liquid. Reference: Wang D, et al. Hum Mol Genet. 2021 Sep 11;ddab235. doi: 10.1093/hmg/ddab235. PMID: 34508586 |
| Mutagen | |
| Outcrossed | x0 |
| Made by | Dandan Wang |
| Laboratory | XMN |
| Reference | Dandan Wang, Maria Dao, Brian S Muntean, Andrew C Giles, Kirill A Martemyanov, Brock Grill, Genetic modeling of GNAO1 disorder delineates mechanisms of Gαo dysfunction, Human Molecular Genetics, 2021;, ddab235, https://doi.org/10.1093/hmg/ddab235 |
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