|Name||XMN1208 View On Wormbase|
|Description||Maintain at 20 C; sick at 23C. goa-1(bgg44[G42R]) replicates a human GNA01 disorder-associated mutation. The GNA01 disorder-associated G42R mutation functions as dominant negative allele in heterozygotes, and loss of function when homozygotes are evaluated in locomotion and aldicarb assays. Hypersensitive to aldicarb: hyperactive waveforms on plates and continuous hyperactivity in automated locomotion assays performed in liquid. Reference: Wang D, et al. Hum Mol Genet. 2021 Sep 11;ddab235. doi: 10.1093/hmg/ddab235. PMID: 34508586|
|Made by||Dandan Wang|
|Reference||Dandan Wang, Maria Dao, Brian S Muntean, Andrew C Giles, Kirill A Martemyanov, Brock Grill, Genetic modeling of GNAO1 disorder delineates mechanisms of Gαo dysfunction, Human Molecular Genetics, 2021;, ddab235, https://doi.org/10.1093/hmg/ddab235|
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