Gene Information: lin-46

Namelin-46 View on WormBase
Species C. elegans
SequenceR186.4
Genetic positionV:4.77 +/- 0.002 cM
Genomic positionV: 12968855..12970730

Strains carrying this gene

Strain Genotype Description
VT1102 lin-28(n719) I; lin-46(ma164) nDf51 V; mir-84(n4037) X. Strong retarded heterochronic phenotype, reiteration of L2-stage program resulting in extra seam cells and failure to generate alae. nDf51 is a 5930 bp deletion starting 1762 bp upstream of mir-241, removing mir-241, mir-48, and F56A12.6 (snoRNA).
VT1145 lin-46(ma164) nDf51 V; mir-84(n4037) X. Strong retarded heterochronic phenotype, reiteration of L2-stage program resulting in extra seam cells and failure to generate alae. Vul. nDf51 is a 5930 bp deletion starting 1762 bp upstream of mir-241, removing mir-241, mir-48, and F56A12.6 (snoRNA).
VT3593 lin-46(ma385) maIs105 V. maIs105 [col-19::GFP]. Retarded heterochronic phenotypes: extra seam cells and alae gaps in young adults. ma385 is a 1681 bp deletion of the lin-46 gene. Reference: Ilbay O & Ambros V. Development. 2019 Nov 6;146(21).
VT3855 lin-46(ma467) maIs105 V. maIs105 [col-19::GFP]. Precocious heterochronic phenotypes: fewer seam cells and protruding vulva in young adults and patches of alae in L4 larvae. ma467 is a 12 bp deletion in the 5'UTR of the lin-46 gene, which results in gain-of-function of lin-46. Reference: Ilbay O & Ambros V. Development. 2019 Nov 6;146(21).
VT581 dpy-5(e61) lin-28(n719) I; lin-46(ma164) unc-76(e911) V. Dpy Unc. Egl+. lin-46 suppresses precocious Egl- phenotype of lin-28. lin-46 alone makes gaps in adult alae; enhanced at 15C.