Gene Information: cho-1

Namecho-1 View on WormBase
Species C. elegans
Genetic positionIV:8.48 +/- 0.003 cM
Genomic positionIV: 13209730..13214566

Strains carrying this gene

Strain Genotype Description
RM1743 cha-1(md39) cho-1(tm373) IV. Temperature-sensitive lethal. Maintain at 15C. At 16-20C: aldicarb-resistant, small, Unc-coily, slow-growing, slow pharyngeal pumping. At 25C: tight coils, virtually no movement, virtually no pumping, no growth, lethal. References: Rand JB. Genetics. 1989 May;122(1):73-80. Mullen GP, et al. Genetics. 2007 Sep;177(1):195-204.
RM2576 cho-1(tm373) IV. Canonical allele. Superficially wild-type. Frequency of spontaneous reversals approximately twice that of wild type. Initial L4 swimming rate approximately half that of wild type, and decreases steadily for 30 min, until the animals are immobile. Synthetic lethal with pmt-2 RNAi.
RM3156 oct-1(gk354) I; cho-1(tm373) IV. Slightly Lon and Unc. Reference: Mullen GP, et al. Genetics. 2007 Sep;177(1):195-204.
RM3157 cho-1(tm373) IV; chtl-1(ok1695) X. Slightly Lon and Unc. Reference: Mullen GP, et al. Genetics. 2007 Sep;177(1):195-204.
RM3218 pha-1(e2123) III; cho-1(tm373) IV; mdEx790. mdEx790 [cho-1p(7.6kb)::cho-1::GFP + pha-1(+) + pBluescript]. CHO-1 translational fusion driven by 7.6 kb cho-1 promoter rescues cho-1 mutant behaviors, including reduced initial thrashing rate, fatigue, and synthetic interactions with pmt-2. Strong fluorescence in nerve ring, and ventral and dorsal nerve cords. Structure of the transgene is shown in Figure 1 of Mullen et al., 2007.
RM3248 oct-1(gk354) I; cho-1(tm373) IV; chtl-1(ok1695) X. Approximately wild-type in appearance, growth, and movement. Reference: Mullen GP, et al. Genetics. 2007 Sep;177(1):195-204.
VC862 cho-1(ok1069) IV. C48D1.3. Superficially wild type.  [NOTE: (06/13/2017) A user has reported that they are unable to identify only ok1069 animals by PCR, so it is possible that this strain carries a deletion/duplication.]  Attribution: This strain was provided by the C. elegans Reverse Genetics Core Facility at the University of British Columbia, which is part of the international C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. Paper_evidence WBPaper00041807