Gene Information: let-7

Namelet-7 View on WormBase
Species C. elegans
SequenceC05G5.6
Genetic positionX:21.22 +/- 0.067 cM
Genomic positionX: 14743590..14745321

Strains carrying this gene

Strain Genotype Description
GR1432 let-7(mg279) X. Weakly retarded differentiation of the hypodermis and exit from the molting cycle. Reference: Hayes GD, Frand AR, Ruvkun G. Development. 2006 Dec;133(23):4631-41.
GR1433 let-7(mg279) mir-84(tm1304) X. Retarded differentiation of the hypodermis and supernumerary molt that results in adult lethality. Reference: Hayes GD, Frand AR, Ruvkun G. Development. 2006 Dec;133(23):4631-41.
GR1452 veIs13 V; let-7(mn112) unc-3(e151) X; mgEx725. veIs13 [col-19::GFP + rol-6(su1006)] V. mgEx725 [lin-4::let-7 + ttx-3::RFP]. Pick RFP+ to maintain. mgEx725 rescues lethality of let-7(mn112). Precocious expression of col-19::GFP at the L4 stage. Reference: Hayes GD, Riedel CG, Ruvkun G. 2011. Genes Dev. 2011 Oct 1;25(19):2079-92.
MT7626 let-7(n2853) X. Temperature sensitive - maintain at 15C. Seam cells divide in L4-to-adult molt. Animals undergo extra molt and explode at vulva. Males have leptoderan-like tail. Animals explode or are sterile at 25C.
NOA1 lin-12(n137n460) III; him-5(e1467) V; let-7(n2853) X.
NOA2 lin-12(n137n460) III; him-5(e1467) V; unc-3(e151) let-7(mn112) X.
PQ425 apIs320 II; unc-119(ed3) III; unc-3(e151) let-7(mn112) X. apIs320 [let-7::unc-119(+)] II. PQ425 was created by crossing PQ320 into unc-3(e151) let-7(mn112) animals, which do not express precursor or mature let-7. unc-119(ed3) might not be homozygous in this strain. Reference: Zisoulis DG, et al. Nature. 2012;486(7404):541-544.
PQ426 apIs404 II; unc-119(ed3) III; unc-3(e151) let-7(mn112) X. apIs404 [let-7(delta alg-1-binding site)::unc-119(+)] II. PQ426 was created by crossing PQ404 into unc-3(e151) let-7(mn112) animals, which do not express precursor or mature let-7. unc-119(ed3) might not be homozygous in this strain. Reference: Zisoulis DG, et al. Nature. 2012;486(7404):541-544.
SP231 mnDp1(X;V)/+ V; unc-3(e151) let-7(mn112) X. LETHAL LATE LARVAL SEX-INFLUENCED Maintain by picking WT.