Gene Information: tph-1

Nametph-1 View on WormBase
Species C. elegans
Genetic positionII:0.50 +/- 0.000 cM
Genomic positionII: 7549335..7551983

Strains carrying this gene

Strain Genotype Description
EEG107 tph-1(mg280) II; mudIs1. mudIs1 [tph-1p::ChR2::GFP + myo-3p::mCherry]. When tph-1 mutants carrying mudIs1 are exposed to blue light, the worms continue to move rather than stopping like wild-type animals. Reference: Pokala N & Glater EE. 2018. Journal of Undergraduate Neuroscience Education. 162(2): A152-A158.
GR1321 tph-1(mg280) cam-1(vs166) II. Slow pumping. Egg laying defective. Low frequency of dauer formation. Residual serotonin immunoreactivity, rare and very faint (<1% of NSMs) in most stages, but nearly 100% of CP neurons in adult males show faint to moderate serotonin immunoreactivity. Males mate quite well (E. Hare and C. Loer). Some phenotypic defects originally attributed to mg280 in this strain are likely due to vs166. vs166 is a large deletion (approx. 9.8kb) in the cam-1 gene; flanking sequences are: 5'-gctactggtaaataaggtaa-3' and 5'-atgcttttaaagtttatatt-3' (Edith Myers, personal commnication). See MT15434 for a strain carrying mg280 without the cam-1 mutation.
GR1333 yzIs71 V. yzIs71 [tph-1p::GFP + rol-6(su1006)] V. Rollers. tph-1 transcriptional reporter containing 3.1kb of tph-1 5’ regulatory sequence through the beginning of exon 4. Reference: Lloret-Fernández et al. eLife 2018;7:e32785 DOI: 10.7554/eLife.32785. Sze JY, et al. Nature. 2000 Feb 3;403(6769):560-4.
GR1366 mgIs42. mgIs42 [tph-1::GFP + rol-6(su1006)]. Rollers.
MT14984 tph-1(n4622) II. Egl. Reduced pharyngeal pumping.
MT15434 tph-1(mg280) II. Backcrossed tph-1(mg280) allele. cam-1 mutation was removed by crossing left and right of tph-1(mg280) using bli-2 and unc-4. Strain does not have withered tail defect and moves well.
OH4127 zdIs13 IV; oyIs14 V; wrk-1(ok695) X. zdIs13 [tph-1p::GFP] IV. oyIs14 [sra-6::GFP + lin-15(+)] V.
OH4134 otIs173 III; zdIs13 IV. otIs173[F25B3.3::DsRed2 + ttx-3promB::GFP] III. zdIs13 [tph-1p::GFP] IV.
OH4135 otIs173 III; zdIs13 IV; wrk-1(ok695) X. otIs173[F25B3.3::DsRed2 + ttx-3promB::GFP]. zdIs13 [tph-1p::GFP] IV.
OH4138 zdIs13 IV; wrk-1(tm1099) X. zdIs13 [tph-1p::GFP] IV.
OH4143 vab-1(dx31) II; zdIs13 IV. zdIs13 [tph-1p::GFP] IV.
OH4144 vab-1(dx31) II; zdIs13 IV; wrk-1(ok695) X. zdIs13 [tph-1p::GFP] IV.
OH4147 zdIs13 IV; wrk-1(ok695) X. zdIs13 [tph-1p::GFP] IV.