Gene Information: lin-41

Namelin-41 View on WormBase
Species C. elegans
SequenceC12C8.3
Genetic positionI:3.75 +/- 0.001 cM
Genomic positionI: 9334800..9342496

Strains carrying this gene

Strain Genotype Description
CT8 lin-41(ma104) I. Dpy. Precocious heterochronic. Reduced brood size. There may be a linked Dpy mutation in this strain.
DG3784 lin-41(tn1487) I. Temperature-sensitive sterile. Maintain at 15C. Reference: Spike CA, et al. Genetics. 2014 Sep 26. pii: genetics.114.168831.
DG3913 lin-41(tn1541[GFP::tev::s::lin-41]) I. lin-41(tn1541[GFP::tev::s::lin-41]) I. May be maintained under normal conditions.
EM101 lin-41(bx37) I; him-5(e1490) V. Maintain under normal conditions. Males have long tail tips.
EM106 lin-41(bx42) I; him-5(e1490) V. Maintain under normal conditions. Males have long tail tips.
HW1329 lin-41(xe11) I. Egg-laying (Egl) defects and subsequent internal hatching of progeny (Bagging) in > 95% of animals. xe11 is a C-to-U point mutation in each of the endogenous let-7 complementary sites, LCS1 and LCS2 [I:C9,335,211T & I:C9,335,260T]. xe11 is a weak gain-of-function allele: mutation of two functionally relevant let-7 binding sites impairs repression by let-7 causing over-expression of LIN-41 in L4 stage animals. Reference: Ecsedi M, et al. Dev Cell. 2015 Feb 9;32(3):335-44. Do not distribute this strain; other labs should request it directly from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
HW1870 lin-41(xe8)/lin-41(bch28[eft-3p::gfp::h2b::tbb-2 3'UTR] xe70) I. Pick GFP+, Egl to maintain. Segregates GFP- lin-41(xe8) homozygotes (die by vulval bursting as young adults), lin-41(xe8)/lin-41(bch28[eft-3p::gfp::h2b::tbb-2 3'UTR] xe70) heterozygotes (GFP+, Egl), and lin-41(bch28[eft-3p::gfp::h2b::tbb-2 3'UTR] xe70) (GFP+, Ste, Dpy). lin-41(xe8) is a deletion of let-7 binding sites in the lin-41 3'UTR. The balancer was derived from lin-41(bch28), a lin-41(0) allele in which an expression cassette that drives ubiquitous nuclear GFP from the eft-3 promoter has been inserted into the lin-41 coding sequence (Katic et al., G3 (2015) 5:1649-56). References: Katic et al., G3 (2015) 5:1649-56 for lin-41(bch28) starting allele for balancer generation. Aeschimann F, et al. (2019). A single let-7 target to coordinate transition to adulthood. Life Science Alliance 2, e201900335. for balanced line. Do not distribute this strain; other labs should request it directly from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
MT7897 lin-41(n2914)/unc-29(e1072) lin-11(n1281) I. Heterozygotes are WT and segregate WT, UncVul and lin-41 (Dpy, Scrawny and Sterile).
NOA3 lin-41(ma104) I; lin-12(n137n460) III.
VT1143 lin-41(ma104) I; nDf51 V; mir-84(n4037) X. Retarded heterochronic phenotype, reiteration of L2-stage program resulting in extra seam cells by the L3 stage and incomplete alae formation. nDf51 is a 5930 bp deletion starting 1762 bp upstream of mir-241, removing mir-241, mir-48, and F56A12.6 (snoRNA).