Gene Information: mig-6

Namemig-6 View on WormBase
Species C. elegans
SequenceC37C3.6
Genetic positionV:0.91 +/- 0.001 cM
Genomic positionV: 7827217..7842390

Strains carrying this gene

Strain Genotype Description
CB3610 mig-6(e1931)/dpy-11(e224) V. Heterozygotes are WT and segregate WT, Dpys, and steriles. mig-6(e1931) hermaphrodites are sterile, with failure of DTC migrations. Gonad sterile, disorganized, otherwise hermaphrodites appear normal. Strain is imperfectly balanced - check for correct segregation of Dpy and Mig from WT hermaphrodites.
NK2442 mig-6(qy37[mNG+loxP::mig-6]) V. Superficially wild-type. CRISPR/Cas9 insertion of mNeonGreen. Insertion site verified by PCR and sequencing.
NK2557 mig-6(qy73[mig-6::mNG+loxP]) V. Superficially wild-type. Specifically tags the long isoform of mig-6. CRISPR/Cas9 insertion of mNeonGreen. Insertion site verified by PCR and sequencing.
NW1313 mig-6(ev700) V. Abnormal distal tip cell migration detectable as clear patches in anterior and posterior. Partially penetrant embryonic arrest and early larval lethal.
NW1314 mig-6(ev701) V. Abnormal distal tip cell migration detectable as clear patches in anterior and posterior. Partially penetrant embryonic arrest and early larval lethal.
NW1619 dpy-11(e224) mig-6(ev700) V/eT1 (III;V). Heterozygotes display abnormal distal tip cell migration detectable as clear patches in anterior and posterior. Heterozygotes segregate WT, Dpy, abnormal DTC migration, Unc, and dead eggs. Maintain by picking wild-type.
NW1623 dpy-11(e224) mig-6(ev788) V/eT1 (III;V). Heterozygotes display partially penetrant (~10%) abnormal distal tip cell migration detectable as clear patches in anterior and posterior. Heterozygotes segregate WT, abnormal DTC migration, Unc, and dead eggs. Maintain by picking wild-type.
NW1625 dpy-11(e224) mig-6(e1931) V/eT1 (III;V). Heterozygotes are wild-type and segregate WT, Dpy-Ste Unc, and dead eggs. Maintain by picking wild-type.
NW1675 mig-6(oz113) V/nT1 [qIs51] (IV;V). Heterozygotes are wild-type and GFP+. Heterozygotes segregate WT GFP+, sterile GFP- homozygotes, and dead eggs. Maintain by picking GFP+ wild-type.
QC104 etIs2 III; mig-6(et4) V. etIs1 [ric-19p::ric-19::GFP + rol-6(su1006). Low levels of ric19::GFP fusion protein expression driven by the ric-19 promoter in all neurons except for strong expression in the pharyngeal M2 neurons. 100% of worms have a twisted pharynx, which is easily seen as a twisted appearance of the M3 neurons.
QC133 mig-6(sa580) V. sa580 is a G-to-A transition that changes a glycine at position 965 to a glutamate in MIG-6. Reference: Jafari M, et al. (2010) Genetics 186:969-982.