Gene Information: unc-44

Nameunc-44 View on WormBase
Species C. elegans
SequenceB0350.2
Genetic positionIV:2.89 +/- 0.000 cM
Genomic positionIV: 5975557..6004857

Strains carrying this gene

Strain Genotype Description
CB1197 unc-44(e1197) IV. Coiler Unc. Growth slow.
CB1260 unc-44(e1260) IV. Paralyzed Unc. Small.
CB362 unc-44(e362) IV. Paralyzed Unc. Small. Recessive. M-MATING-NO SUCCESS.
CZ24990 unc-44(ju1412[unc-44::GFP]) IV. Endogenous unc-44 locus tagged for UNC-44L::GFP expression. The long isoform of UNC-44 is specific to neuronal expression. Reference: Chen F, Chisholm AD, Jin Y. Development. 2017 Feb 15;144(4):698-707.
CZ25013 unc-44(ju1413[unc-44::gfp::LoxP::3xflag]) IV. unc-44(ju1413[unc-44::GFP::LoxP::3xflag]) IV. UNC-44C (short isoform of UNC-44) tagged with GFP. UNC-44C is strongly expressed in multiple tissues: nervous system (from 1.5-fold stage to adult), epidermis (from early embryo to adult), seam cells (from L1 to L4), vulva (from L3 to adult), and spermatheca/sheath cells (from L4 to adult). Reference: Chen F, Chisholm AD, Jin Y. Development. 2017 Feb 15;144(4):698-707.
DR1213 unc-44(e362) unc-24(e138) IV. Unc-44 masks the Unc-24 phenotype. Paralyzed coiler, Dpy, tends to curl.
EH135 unc-44(e362) bli-6(sc16) IV. Blistered. Unc.
MT5241 unc-5(e53) unc-44(e362) IV. Unc.
RW1350 unc-44(e362) unc-82(e1323)/stDf7 IV. Segregates heterozygotes that display only the unc-82 phenotype: slow but normal movement, disorganized muscle structure, somewhat Egl. stDf7 homozygotes die as embyros. unc-44 unc-82 homozygotes generally die as coiled, poorly-moving larvae.
RW3562 unc-44(e362) deb-1(st555)/unc-82(e1323) unc-24(e138) IV. Heterozygotes are WT and segregate WT, Uncs (unc-82 unc-24 homozygotes) and dead eggs (unc-44 deb-1 homozygotes).
STR237 unc-44(hrt2) IV. Severely Unc. CRISPR-generated deletion removes 111 bp (ACGATAAGAAAACTA...ATGAATCCGCCCAAG). hrt2 allele is specific to the AO13 unc-44 isoform. Reference: He L, et al. eLife 2020;9:e55111 doi: 10.7554/eLife.55111.
STR282 unc-44(hrt5[unc-44::GFP]) IV. CRISPR/Cas9-engineered insertion of GFP tag into the large AO13 splice isoform of the endogenous unc-44 locus at amino acid 6303. Slightly reduced body bends while crawling. Reference: He L, et al. eLife 2020;9:e55111 doi: 10.7554/eLife.55111.
SU62 unc-44(e1260) lag-1(q385)/zen-4(w35) IV. Heterozygotes are WT and segregate WT, Unc L1 lethals and dead eggs (homozygous zen-4(w35)).