Gene Information: unc-8

Nameunc-8 View on WormBase
Species C. elegans
Genetic positionIV:3.29 +/- 0.001 cM
Genomic positionIV: 7197153..7203660

Strains carrying this gene

Strain Genotype Description
CB15 unc-8(e15) IV. Unc.
CB49 unc-8(e49) IV. Unc.
DR439 unc-8(e49) dpy-20(e1282) IV. DpyUnc.
DR442 unc-8(e49) daf-14(m77) IV. Temperature sensitive dauer constitutive. Unc.
DR641 ama-1(m118m221) unc-8(e15)/nT1 IV; +/nT1 V. Heterozygotes are semi-Unc and segregate semi-Unc and Vul and dead eggs. (Does not segregate Unc homozygotes because linked to the unc is a lethal in the amanitin gene.)
DR645 ama-1(m118) unc-8(e15) IV.
EU592 unc-8(n491) zen-4(or153) IV. Temperature sensitive. Grow at permissive temperature of 15C. Fully penetrant cytokinesis defect at the restrictive temperature of 25C. Semi-dominant Unc.
MP109 unc-8(lb109) IV. Coils. Backs fairly well. The coiling phenotype is semi-dominant.
MP125 unc-8(n491) sup-41(lb125) IV; deg-1(u38) X. Animals move sluggishly but are able to back, despite n491. lb125 also partially suppresses the tail touch insensitive phenotype of u38 in cold-sensitive fashion: at 25C -> 0%; at 20C -> 5%; at 15C -> 30%.
MP130 sup-40(lb130)/+ I; unc-8(e15) IV; egl-1(n487) V. lb130/+ dominantly suppresses the e15 backing defect and causes recessive sterility. Three phenotypes are present in this strain: backing steriles (lb130 homozygotes), backing fertiles which are bloated (heterozygotes), and non-backing coiled Unc animals which are fertile and bloated (sup-40(+)). Maintain strain by picking fertile animals which can back. egl-1(n487) is included in the strain to facilitate identification of lb130 homozygotes, which grow slowly; their sterility contrasts with the bloating of lb130/+ heterozygotes.
MP145 unc-8(e15lb145) IV. Intragenic unc-8 revertant. Appears wild type. Probable null allele.
MP150 unc-8(e15) IV; lbEx9. lbEx9 [R31A1(cosmid) + rol-6(su1006)]. Pick non-Unc Rol to maintain. This strain was obtained by co-injection of plasmid pRF4 and cosmid R13A1 into gonads of unc-8(e15) animals. Reference: Shreffler W, Wolinsky E. Behav Genet. 1997 May;27(3):211-21.
MP151 unc-8(e15) IV; sup-42(lb88) X. WT. lb88 is a recessive X-linked suppressor of unc-8 dominant mutations.
MP152 dpy-13(e184) unc-8(e15lb55) IV. Dpy.
MP153 unc-8(n491) IV; sup-42(lb88) X. WT.
MP154 unc-8(e15) IV; egl-15(n484) sup-42(lb88) X. Egl. Unc slightly suppressed; the animals will usually back some. [unc-8(e15); egl-15(n484) animals are extremely Unc and will not back.]
MP155 sup-43(lb141) II; unc-8(e49) IV. Animals have nearly WT movement. lb141 is an allele-specific recessive suppressor of e49.
MP82 unc-8(n491lb82) IV. WT. n491lb82/++ trans heterozygotes coil and back very poorly.
MP84 dpy-5(e61) mec-6(lb84) I; unc-8(n491) IV. Dpy.
MT1085 unc-8(n491) IV. Coiler Unc. Dominant.
MT1086 unc-8(n492) IV. Semi-dominant curly Unc.
MT1584 unc-8(e49) egl-19(n582) IV. Unc. Egl.
MT1600 unc-8(e49) egl-21(n611) IV. Temperature-sensitive Egl. Reference: Genetics (1983) 104:619-47.
MT1652 unc-8(n773) IV. Semi-dominant Unc.
MT1672 unc-8(n491) dpy-4(e1166) IV. Dpy. Unc.
MT2136 lin-3(n1058)/unc-8(e49) dpy-20(e1362) IV. Heterozygotes are WT and segregate WT, DpyUnc and Steriles (n1058 homozygotes). The n1058 homozygous larvae are occasionally paralyzed. Maintain by picking WT.
MT2537 dpy-13(e184) unc-8(n491) IV; him-5(e1490) V. DpyUnc. e184 and n491 are both semi-dominant.
MT2611 unc-8(n491n1192) IV. WT revertant.
MT2612 unc-8(n491n1193) IV. WT. Intragenic revertant.
MT2613 unc-8(n491n1194) IV. WT revertant.
MT2614 unc-8(n492n1197) IV. WT revertant.
MT2615 unc-8(n492n1198) IV. WT revertant.
MT2616 unc-8(n491n1195) IV. WT revertant.
MT2617 unc-8(n491n1196) IV. WT revertant.
MT2618 unc-8(n492n1199) IV. WT revertant.