Gene Information: lin-45

Namelin-45 View on WormBase
Species C. elegans
SequenceY73B6A.5
Genetic positionIV:3.23 +/- 0.002 cM
Genomic positionIV: 6742537..6748572

Strains carrying this gene

Strain Genotype Description
BS3347 lin-45(dx84) IV/nT1 [unc-?(n754) let-?] (IV;V). Heterozygotes are Unc and segregate Unc heterozygotes, non-Unc Steriles (lin-45 homozygotes), larval lethals, and dead eggs. dx84 is a strong lin-45 raf allele: dx84 homozygotes from dx84/+ heterozygotes are 47% larval lethal and among the adults, 100% are Sterile and Vul.
BS5183 lin-45(oz201) IV/nT1 [unc-?(n754) let-?] (IV;V). Heterozygotes are Unc and segregate Unc, non-Unc Steriles, larval lethals, and dead eggs. oz201 is a strong lin-45 raf allele: oz201 homozygotes from oz201/+ heterozygotes segregate 55% larval lethal and the remaining adults are all Sterile and Vul.
CZ252 itr-1(n2559)/lin-45(n2018) unc-24(e138) IV. Heterozygotes are WT and segregate WT, Unc Lins and very slow growing constipated worms. n2559 is a null allele of itr-1.
EJ521 lin-45(dx19) IV/nT1 [unc-?(n754) let-?] (IV;V). Heterozygotes are Unc and segregate Unc, non-Unc Steriles, larval lethals and dead eggs. dx19 is a strong lin-45 raf allele: dx19 homozygotes from dx19/+ heterozygous parents are 13% larval lethal and among the adults, 100% are Sterile and Vul.
MH575 lin-45(ku51) dpy-20(e1282) IV. Weak hypomorphic allele of lin-45. Animals are Dpy but otherwise appear normal.
MH620 lin-45(ku112) dpy-20(e1282) IV. Weak hypomorphic allele of lin-45. Animals are Dpy but otherwise appear normal. Occasional larval lethality.
MT4867 unc-5(e53) lin-45(n2018) IV. Unc. n2018 is cold sensitive. Most animals at 15C are Vul/Let. AT 25C, 25% of the animals are non-Vul.
MT6378 lin-45(n2506) let-60(n1046) IV. n2506 suppresses n1046.
MT7052 lin-45(sy96) unc-24(e138) IV.
MT7620 lin-45(n2506) unc-24(e138)/bli-6(sc16) unc-24(e138) IV. Heterozygotes are Unc and segregate Unc, UncVul, and BliUnc.
PJ1092 lin-45(sy96) IV; ccIs55 V. ccIs55 [unc-54::lacZ + sup-7(st5)] V.
PJ1099 lin-45(sy96) let-60(ga89) IV; ccIs55 V. ccIs55 [unc-54::lacZ + sup-7(st5)] V. Vul. Non-Clr at 25C. Poor growers (sub-viable?) at 25C.
PJ1110 clr-1(e1745) II; lin-45(sy96) IV; ccIs55 V. ccIs55 [unc-54::lacZ + sup-7(st5)] V. sy96 appears to suppress the Clr phenotype of e1745. Lots of Bags and larval lethals.
PS427 lin-45(sy96) IV. Vulvaless. 90% of the progeny are larval lethal-most die as L1s. Males are mating defective. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
WU144 lin-45(n1924) unc-24(e138) IV. Weak lin-45 raf allele: 5% larval lethal. Otherwise, essentially WT vulval induction and fertility. n1924 effectively suppresses the let-60(n1046gf) Muv phenotype. Unc.
WU48 lin-45(n2018) dpy-20(e1282) IV. Intermediate severity of lin-45 raf allele: at 20C, 76% larval lethal and 24% display an abnormal vulva (either Egl, no discernable vulva, or PVul). Medium Dpy. Received new stock 11/2002.
WU49 lin-45(n2506) unc-24(e138) IV. Intermediate strength lin-45 raf allele: 86% larval lethal, 93% of adults display an abnormal vulva (either Egl, no discernable vulva, or PVul), and 3% of adults are Sterile. Unc.
WU51 lin-45(n2520) unc-24(e138) IV. Weak severity of lin-45 raf allele: WT viability, vulval induction and fertility but effectively suppresses the let-60(n1046gf) Muv phenotype. Unc.
WU53 lin-45(n1925) unc-24(e138) IV. Weak lin-45 raf allele: essentially WT viability, vulval induction and fertility but effectively suppresses the let-60(n1046gf) Muv phenotype. Unc.
WU57 lin-45(n2510) unc-24(e138)/unc-5(e53) dpy-20(e1282) IV. Heterozygotes are non-Unc and segregate non-Unc, Sterile Unc, and Dpy Unc. n2510 is a strong lin-45 raf allele: 100% of homozygotes are Sterile and Vul (no discernable vulva) or larval lethal.