Gene Information: unc-70

Nameunc-70 View on WormBase
Species C. elegans
SequenceK11C4.3
Genetic positionV:0.42 +/- 0.022 cM
Genomic positionV: 6881338..6891839

Strains carrying this gene

Strain Genotype Description
BC2303 dpy-18(e364)/eT1 III; unc-46(e177) unc-70(s1502)/eT1 V. Heterozygotes are WT and segregate WT, Uncs and DpyUnc Lets that hatch.
BC2440 dpy-18(e364)/eT1 III; unc-46(e177) unc-70(s1639)/eT1 V. Heterozygotes are WT and segregate WT, Uncs, and DpyUnc Lets that hatch.
CB524 unc-70(e524) V. Unc. Semi-dominant at 25C. M-MATING+++ 10-30%WT.
GOU3103 unc-70(cas962[GFP::unc-70]) V. GFP inserted at the N-terminus of the endogenous unc-70 locus. Reference: Jia R, et al. (2019). Spectrin-based Membrane Skeleton Supports Ciliogenesis. PLoS Biology.
GOU3237 unc-70(cas983) V. unc-70(cas983) removes nine amino acids (H590-L598) in the SCA5-associated deletion in β-spectrin by Cas9-triggered homologous recombination. Reference: Jia R, et al. (2019). Spectrin-based Membrane Skeleton Supports Ciliogenesis. PLoS Biology.
GOU3601 unc-70(cas1050[unc-70(delta H590-L598)::GFP]) V. unc-70(cas1050) removes nine amino acids (H590-L598) in the SCA5-associated deletion in β-spectrin and inserts GFP at N-terminus of the endogenous unc-70 locus. Reference: Jia R, et al. (2019). Spectrin-based Membrane Skeleton Supports Ciliogenesis. PLoS Biology.
MT1676 unc-70(n493) dpy-11(e224) V. DpyUnc. Semidominant Unc.
MT2590 +/eT1 III; dpy-11(e224) unc-70(n493n1171)/eT1 V. Heterozygotes are WT and segregate WT, Unc-36 (eT1 homozygotes), arrested larvae (n493n1171 homozygotes) and dead eggs.
MT2591 +/eT1 III; dpy-11(e224) unc-70(n493n1172)/eT1 V. Heterozygotes are WT and segregate WT, Unc-36 (eT1 homozygotes), arrested larvae (n493n1172 homozygotes) and dead eggs.
MT2592 +/eT1 III; dpy-11(e224) unc-70(n493n1173)/eT1 V. Heterozygotes are WT and segregate WT, Unc-36 (eT1 homozygtes), arrested larvae (n493n1173 homozygotes) and dead eggs.
MT4818 unc-70(n493) V. Semi-dominant Unc.
XE1002 unc-70(s1502) V; oxIs12 X. oxIs12 [unc-47p::GFP + lin-15(+)]. Unc. Reference: Hammarlund M, et al. J Cell Biol. 2000 May 15;149(4):931-42.