Gene Information: unc-24

Nameunc-24 View on WormBase
Species C. elegans
SequenceF57H12.2
Genetic positionIV:3.51 +/- 0.004 cM
Genomic positionIV: 7979870..7982011

Strains carrying this gene

Strain Genotype Description
OH7566 mgIs18 unc-24(e138) nhr-67(ot407) IV; ntIs1 V; otEx3103. mgIs18 [ttx-3p::GFP] IV. ntIs1 [gcy-5p::GFP + lin-15(+)] V. otEx3103 [elt-2::GFP]. All worms have mgIs18 and ntIs1. mgIs18 labels AIY interneurons. ntIs1 marks one GFP+ neuron (ASER) in the head. otEx3103 [elt-2::GFP] is expressed in intestinal cells; maintain by picking animals with intestinal GFP. Worms that have lost the array are Emb, Lvl, and have an ASE defect.
PS2366 itr-1(sy328) unc-24(e138) IV. Suppresses sterility of lin-3(n1058) and let-23(sy10). Not involved in vulva development. Synthetic sterile in combination with lfe-2(sy326). Previously called lfe-1. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
PS2368 itr-1(sy327) unc-24(e138) IV. Suppresses sterility of lin-3(n1058) and let-23(sy10). Not involved in vulva development. Synthetic sterile in combination with lfe-2(sy326). Previously called lfe-1. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
PS2512 itr-1(sy331) unc-24(e138) IV. Suppresses sterility of lin-3(n1058) and let-23(sy10). Not involved in vulva development. Synthetic sterile in combination with lfe-2(sy326). Previously called lfe-1. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
PS2516 itr-1(sy291) unc-24(e138) IV. Suppresses sterility of lin-3(n1058) and let-23(sy10). Not involved in vulva development. Synthetic sterile in combination with lfe-2(sy326). Previously called lfe-1. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
PS2582 itr-1(sy290) unc-24(e138) IV. Suppresses sterility of lin-3(n1058) and let-23(sy10). Not involved in vulva development. Synthetic sterile in combination with lfe-2(sy326). Previously called lfe-1. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
PS536 unc-24(e138) let-60(sy99) IV/nT1 [let-?(m435)] (IV;V). Heterozygotes are Vul (97% Egl). Segregates dead eggs. sy99 homozygotes are lethal. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
PS538 unc-24(e138) let-60(sy92) IV/nT1 [let-?(m435)] (IV;V). Heterozygotes are Vul and segregate Vul, Unc-24 lethals and dead eggs. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
RW1324 fem-1(e1991) unc-24(e138) unc-22(s12)/stDf7 IV. Heterozygotes have Unc-24 phenotype and segregate additional hets, embryonic lethals (stDf7/stDf7) and Unc females (or sometimes hermaphrodites) that Twitch.
RW1333 fem-1(e1991) unc-24(e138) unc-22(s12)/stDf8 IV. Heterozygotes have Unc-24 phenotype and segregate additional hets, embryonic lethals (stDf8/stDf8) and Unc females (or sometimes hermaphrodites) that Twitch.
RW3562 unc-44(e362) deb-1(st555)/unc-82(e1323) unc-24(e138) IV. Heterozygotes are WT and segregate WT, Uncs (unc-82 unc-24 homozygotes) and dead eggs (unc-44 deb-1 homozygotes).
RW3563 egl-19(st556)/unc-82(e1323) unc-24(e138) IV. Heterozygotes are WT and segregate WT, Uncs, and Pats. Maintain by picking WT and checking for correct segregation of progeny. st556 pka pat-5.
RW3616 deb-1(st554)/unc-5(e53) unc-24(e138) IV. Heterozygotes are WT and segregate WT, Uncs and Pats. Maintain by picking WT and checking for correct segregation of progeny. Received new stock from Waterston lab 5/98. st554 previously called pat-8.
SM1052 zen-4(px47) dpy-20(e1282)/bli-6(sc16) unc-24(e138) Heterozygotes are WT and segregate WT, Bli Uncs, and dead embryos and L1s (with Pun phenotype).
SP1471 unc-24(e138) dpy-20(e1282) IV.
SS615 pgl-1(bn101) unc-24(e138) IV; pgl-3(bn104) dpy-11(e224) V. Dpy Unc. Temperature sensitive. Maintain at 15C. Grows very slowly.
SS617 pgl-1(ct131) him-3(e1147) unc-24(e138) IV; pgl-3(bn104) dpy-11(e224) V. Throws males. Dpy. Unc. Mostly sterile at all temperatures, but a small fraction are fertile at low temperatures. Maintain at 15C.
SS730 pgl-2(bn123) III; pgl-1(bn101) unc-24(e138) IV. Unc. Maintain at 15C. Sterile at higher temperatures.
SS733 pgl-2(bn123) III; pgl-1(bn101) unc-24(e138) IV; pgl-3(bn104) dpy-11(e224) V. Dpy. Unc. Mostly sterile at all temperatures, but a small fraction are fertile at low temperatures. Maintain at 15C.
ST14 mua-5(nc14)/bli-6(sc16) egl-19(n582) unc-24(e138) IV. Heterozygotes are WT and segregate WT, BliEglUnc, and animals with muscle attachment defects and ventral cord displacement and detachment which arrest in larval development. Not well balanced.
ST15 ncIs2 II; mua-5(nc15)/bli-6(sc16) egl-19(n582) unc-24(e138) IV. ncIs2 [pH20::GFP + pBlueScript]. Heterozygotes are WT and segregate WT, BliEglUnc, and animals with muscle attachment defects and ventral cord displacement and detachment which arrest in larval development. Not well balanced. Neurons visualized with ncIs2.
ST17 mua-5(nc17)/bli-6(sc16) egl-19(n582) unc-24(e138) IV. Heterozygotes are WT and segregate WT, BliEglUnc, and animals with muscle attachment defects and ventral cord displacement and detachment which arrest in larval development. Not well balanced.
ST18 mua-5(nc18)/bli-6(sc16) egl-19(n582) unc-24(e138) IV. Heterozygotes are WT and segregate WT, BliEglUnc, and animals with muscle attachment defects and ventral cord displacement and detachment which arrest in larval development. Not well balanced.
WM101 unc-24(e138) oma-1(ne411) IV; lon-2(e678) X. Lon. Maintain at 15C. Produces dead eggs at 25C.
WU144 lin-45(n1924) unc-24(e138) IV. Weak lin-45 raf allele: 5% larval lethal. Otherwise, essentially WT vulval induction and fertility. n1924 effectively suppresses the let-60(n1046gf) Muv phenotype. Unc.
WU49 lin-45(n2506) unc-24(e138) IV. Intermediate strength lin-45 raf allele: 86% larval lethal, 93% of adults display an abnormal vulva (either Egl, no discernable vulva, or PVul), and 3% of adults are Sterile. Unc.
WU51 lin-45(n2520) unc-24(e138) IV. Weak severity of lin-45 raf allele: WT viability, vulval induction and fertility but effectively suppresses the let-60(n1046gf) Muv phenotype. Unc.
WU53 lin-45(n1925) unc-24(e138) IV. Weak lin-45 raf allele: essentially WT viability, vulval induction and fertility but effectively suppresses the let-60(n1046gf) Muv phenotype. Unc.
WU57 lin-45(n2510) unc-24(e138)/unc-5(e53) dpy-20(e1282) IV. Heterozygotes are non-Unc and segregate non-Unc, Sterile Unc, and Dpy Unc. n2510 is a strong lin-45 raf allele: 100% of homozygotes are Sterile and Vul (no discernable vulva) or larval lethal.
XM1002 vab-1(dx31) III; itr-1(sy290) unc-24(e138) IV. vab-1 null and itr-1 gain of function. Viable. Unc.