Gene Information: unc-24

Nameunc-24 View on WormBase
Species C. elegans
SequenceF57H12.2
Genetic positionIV:3.51 +/- 0.004 cM
Genomic positionIV: 7979870..7982011

Strains carrying this gene

Strain Genotype Description
BA968 spe-29(it127) unc-24(e138) IV. Unc. Leaky sterile at 20C; tighter at 16C and 25C. Easier to propagate as if male-female strain.
BT14 fbl-1(hd43)/dpy-20(e1282) unc-24(e138) IV. Heterozygotes are WT and segregate WT, Steriles (hd43 homozygotes) and Dpy Uncs.
CA448 unc-24(e138) zim-3(tm2303) IV. Unc. Weak Him. Produces unhatched eggs.
CB1172 unc-24(e1172) IV. Unc.
CB138 unc-24(e138) IV. Weak kinker.
CB3823 eDf18/unc-24(e138) dpy-20(e1282) IV. Heterozygotes are WT and segregate WT, DpyUnc and dead eggs. Maintain by picking WT.
CB3824 eDf19/unc-24(e138) dpy-20(e1282) IV. Heterozygotes are WT (somewhat Unc and Egl) and segregate WT, DpyUnc and dead eggs. Maintain by picking WT.
CB3843 fem-3(e1996)/unc-24(e138) dpy-20(e1282) IV. Heterozygotes are WT and segregate WT, DpyUnc and fertile females.
CB4227 sup-34(e2227) I; unc-24(e138) dpy-20(e2017) IV. sup-34 is dominant amber suppressor: weak suppression of Unc, medium suppression of Dpy.
CB448 unc-24(e448) IV. Unc. Recessive.
CB4747 dpy-20(e2017) unc-24(e138) IV; sup-33(st389) X. Variable phenotypes, slightly dumpy and/or uncoordinated, especially at 25C. Grows poorly at 15C. Low fertility. sup-33(st389) is a weak amber suppressor; e2017 and e138 are amber mutations. Reference: Kondo K, et al. (1990) J Mol Biol. 1990 Sep 5;215(1):7-19.
CB4760 fem-1(e2044) mor-2(e1125) unc-24(e158) fem-3(q20) / unc-5(e53) dpy-20(e1282) IV Wild-type hermaphrodites segregating wild-type hermaphrodites, Unc-24 females, Unc Dpy hermaphrodites. Maintain by picking wild-type hermaphrodites. Deletion allele of fem-1, with unusual maternal effect. Reference: Spence AM, et al. Cell. 1990 Mar 23;60(6):981-90. Johnson CL & Spence AM.. Science. 2011 Sep 2;333(6047):1311-4.
CF978 unc-24(e138) IV; bar-1(mu349) X. Unc. QL descendants in a mutant position (anterior of ALM). Okay to grow at 15 or 20C.
CZ252 itr-1(n2559)/lin-45(n2018) unc-24(e138) IV. Heterozygotes are WT and segregate WT, Unc Lins and very slow growing constipated worms. n2559 is a null allele of itr-1.
DA1025 vab- (ad1026); egl-19(ad1025)/bli-6(sc16) unc-24(e138) IV. Impenetrant Vab - mostly tail; not mapped. Strain throws early larval lethals (ad1025 homozygotes) and Bli Uncs.
DA1042 egl-19(ad1008) unc-24(e138) IV/nT1 [unc-?(n754) let-?] (IV;V) Heterozygotes are Unc and segregate Uncs and dead eggs. ad1008 homozygotes are Pat.
DA740 bli-6(sc16) unc-24(e138) IV. Blistered Unc.
DA768 bli-6(sc16) egl-19(ad695) unc-24(e138)/nDf41 IV. Heterozygotes are Blistered and Eat (terminal bulb relaxation defective). Heterozygotes segregate BliEat, BliEatUnc and dead eggs. ad695 previously called eat-12.
DA929 egl-19(n582) unc-24(e138) IV. Unc: amber suppressible. Egl: Lon, slow and floppy.
DA949 bli-6(sc16) egl-19(n582) unc-24(e138) IV. Blistered cuticle. Egl-Lon, slow and floppy. Unc.
DF22 tlp-1(bx85) unc-24(e138) IV; him-5(e1490) V. Unc. Although hermaphrodites appear WT in other ways, there are some problems with T cell lineages (affecting the phasmids) and tail cell fusions. Variably Dyf. Male tail tip morphogenesis is also defective, resulting in blobby, "leptoderan" tails. Males are infertile due to an inability to properly copulate.
DR106 unc-24(e1172) dpy-4(e1166) IV. DpyUnc.
DR1213 unc-44(e362) unc-24(e138) IV. Unc-44 masks the Unc-24 phenotype. Paralyzed coiler, Dpy, tends to curl.
DR1786 dpy-13(e184) unc-24(e138) IV; mDp4[unc-17(e245)] (IV;?). WT phenotype. Segregates WT and DpyUncs. mDp4 carries dpy-13(+) and unc-24(+). Duplication may recombine with normal homologues. Presence of unc-17(e245) on mDp4 confirmed: got Unc-17 segregants after heat shock of this stock to generate males. Pick WT and check for segregation of progeny to maintain.
DR190 dpy-13(e184) unc-24(e138) IV. Dpy. Unc.
DR202 unc-24(e138) daf-14(m77) IV. Temperature sensitive dauer constitutive. Unc.
DR412 daf-15(m81)/unc-24(e138) IV. Heterozygotes are WT and segregate WT, Unc, and lethal dauers. Dauers are SDS-sensitive.
GE2001 xpf-1(e1487) II; unc-24(e138) IV/nT1(IV;V); dpy-11(e224) ccz-1(t2070) V/nT1 (IV;V). Him. Wild-type heterozygotes segregate WT heterozygotes and Dpy Unc ccz-1 homozygotes (produce only arrested embryos). ccz-1 embryos have spindle orientation defects, accumulate vesicles, and problems engulfing apoptotic corpses. Reference: Nieto C, et al. J Cell Sci. 2010 Jun 15;123(Pt 12):2001-7.
GE2516 xpf-1(e1487) II; unc-24(e138) IV/nT1(IV;V); dpy-11(e224) ccz-1(t2071) V/nT1 (IV;V). Him. Wild-type heterozygotes segregate WT heterozygotes and Dpy Unc ccz-1 homozygotes (produce only arrested embryos). ccz-1 embryos have spindle orientation defects, accumulate vesicles, and problems engulfing apoptotic corpses. Reference: Nieto C, et al. J Cell Sci. 2010 Jun 15;123(Pt 12):2001-7.
GS367 evl-23(ar106)/dpy-13(e184) unc-24(e138) IV. Heterozygotes are WT and segregate WT, Steriles with and Everted Vul and DpyUncs. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
GS368 evl-13(ar107)/dpy-13(e184) unc-24(e138) IV. Heterozygotes are WT and segregate WT, Steriles with and Everted Vul and DpyUncs. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
GS369 evl-7(ar108)/dpy-13(e184) unc-24(e138) IV. Heterozygotes are WT and segregate WT, DpyUncs and Steriles which have an everted vulva. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
GS416 evl-6(ar120)/dpy-13(e184) unc-24(e138) IV. Heterozygotes are WT (Dpyish) and segregate WT (Dpyish), DpyUncs and Steriles which have an everted vulva. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
GS431 evl-24(ar124)/dpy-13(e184) unc-24(e138) IV. Heterozygotes are WT and segregate WT, DpyUncs and Steriles which have an everted vulva. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
HR83 mel-24(ct59) dpy-20(e1282)/unc-24(e138) daf-15(m81) IV. Heterozygotes are WT and segregate WT, Unc Dauers, and Dpys which throw dead eggs. Maintain by picking WT. ct59 animals are viable and fertile at 15C. ct59 is a temperature sensitive dominant maternal effect lethal. ct59 hets give more viable offspring at 15C than 25C.
JH1580 unc-24(e1172) mbk-2(pk1427) IV/nT1 [let-?(m435)] (IV;V). Heterozygotes are WT and segregate WT, Uncs which give only dead eggs, and dead eggs. mbk-2(pk1427) is a deletion that removes most of the mbk-2 locus.
JH2932 unc-24(e1172) mbk-2(pk1427) IV/nT1[let-?(m435)] (IV;V); ddEx16. ddEx16 [pgl-1::TY1::EGFP::3xFLAG(92C12) + Cbr-unc-119(+)]. Maintain at 25C to retain transgene expression. Heterozygotes are Unc and segregate Uncs, dead eggs and WT. Reference: Wang JT, et al. eLife 2014;3:e04591.
JJ1129 elt-1(zu180) unc-43(e408)/unc-24(e138) dpy-20(e1282) IV. Heterozygotes are WT and segregate WT, DpyUncs and dead eggs.
JJ938 unc-24(e138) daf-14(m77)/elt-1(zu180) dpy-20(e1282) IV. At 20C or 25C, heterozygotes are WT and segregate WT, UncDaf and dead eggs. At 15C, heterozygotes are WT and segregate WT, Uncs and dead eggs.
JK1227 lag-1(q385)/dpy-13(e184) unc-24(e138) IV. Heterozygotes are WT and segregate WT, DpyUnc and early larval lethals. Received new stock 5/98. Check carefully for segregation of Dpy Unc progeny; dpy-13 can be lost easily. Do not distribute this strain; other labs should request it from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.
JR2750 bli-6(sc16) unc-22(e66)/unc-24(e138) vha-17(w13) dpy-20(e2017) IV. Pick wild type animals to maintain.
JT9819 unc-24(e138) lin-49(s1198) unc-22(s7) IV/nT1 [unc-?(n754) let-?] (IV;V). Heterozygotes are Unc and segregate Unc, lethal Twitchers and dead eggs. Twitchers arrest in early-mid larval development. See also WBPaper00003938.
KJ487 vha-8(jh135)/bli-6(sc16) egl-19(ad695) unc-24(e318) IV. Heterozygotes are WT and segregate WT, Bli Unc, and dead larva. vha-8(jh135) homozygotes are larval lethal.
ML732 vha-5(mc38)/unc-24(e138) dpy-20(e1282) IV. Heterozygotes are WT and segregate WT, DpyUncs, and dead L1 larvae that are translucent and often found away from the bacterial lawn (can be difficult to spot on the lawn).
MT12024 unc-24(e138) dpy-20(e1282) IV. Dpy (ts). Unc (amber).
MT4244 unc-24(e138) let-60(n1046) IV. Unc. Muv (sd, gf).
MT4684 lin-3(n1059) dpy-20(e1362)/unc-24(e138) mec-3(e1338) dpy-20(e1282) IV. Heterozygotes are Dpy and segregate Dpy, Dpy Lethals (early larval) and DpyUncMec.
MT7052 lin-45(sy96) unc-24(e138) IV.
MT7620 lin-45(n2506) unc-24(e138)/bli-6(sc16) unc-24(e138) IV. Heterozygotes are Unc and segregate Unc, UncVul, and BliUnc.
MT8998 unc-24(e138) sqv-1(n2819) IV/nT1 [unc-?(n754) let-?] (IV;V). Heterozygotes are Unc and segregate Uncs, SqvUncs and dead eggs. n2819: mid-L4 vulva abnormal, sterile.