Gene Information: sek-1

Namesek-1 View on WormBase
Species C. elegans
SequenceR03G5.2
Genetic positionX:-1.14 +/- 0.032 cM
Genomic positionX: 7816734..7821036

Strains carrying this gene

Strain Genotype Description
AU1 sek-1(ag1) X. Enhanced susceptibility to pathogens (Esp). Egl-d. Nsy. Also called esp-2.
AU37 glp-4(bn2) I; sek-1(km4) X. Temperature sensitive sterility. Maintain at 15C. Enhanced sensitivity to pathogens.
ENL65 sma-10(ok2224) IV; sek-1(km4) X. Derived from RB1739 and KU4.
FK171 mek-1(ks54) sek-1(qd127) X. Hypersensitive to copper and cadmium ions, and to starvation. [NOTE: Prior studies suggested possible cross-regulation of PMK-1 by MEK-1, but the identification of a tightly linked partial loss-of-function mutation in sek-1(qd127) in the strain carrying the mek-1(ks54) mutant allele (K. Reddy and D. Kim, unpublished data) suggests that the diminished PMK-1 activation observed in this mutant strain may actually be due to diminished SEK-1 activity.]
KU4 sek-1(km4) X. Egl. 2.1 kb deletion.
ZD193 sek-1(km4) X; qdEx4. qdEx4 [ges-1p::sek-1(cDNA)::GFP::unc-54-3' UTR + myo-2p::mStrawberry::unc-54-3' UTR]. Array rescues sek-1 in the intestine. References: Shivers RP, et al. Cell Host Microbe. 2009 Oct 22;6(4):321-30.
ZD202 sek-1(km4) X; qdEx8. qdEx8 [unc-119p::sek-1(cDNA)::GFP::unc-54-3' UTR + myo-2p::mStrawberry::unc-54-3' UTR]. Array rescues sek-1 in neurons. References: Shivers RP, et al. Cell Host Microbe. 2009 Oct 22;6(4):321-30.
ZD260 sek-1(km4) X; qdEx11. qdEx11 [osm-5p::sek-1(cDNA)::GFP::unc-54-3' UTR + myo-2p::mStrawberry::unc-54-3' UTR]. Array rescues sek-1 in ciliated sensory neurons. References: Shivers RP, et al. Cell Host Microbe. 2009 Oct 22;6(4):321-30.
ZD340 agIs219 atf-7(qd22qd130) III; sek-1(km4) X. agIs219 [T24B8.5p::GFP::unc-54-3' UTR + ttx-3p::GFP::unc-54-3' UTR] III. atf-7(qd22 qd130) suppresses increased pathogen susceptibiliy (Esp) of sek-1(km4). References: Shivers RP, et al. PLoS Genet. 2010 Apr 1;6(4):e1000892.