Gene Information: unc-13

Nameunc-13 View on WormBase
Species C. elegans
SequenceZK524.2
Genetic positionI:2.07 +/- 0.004 cM
Genomic positionI: 7422785..7454116

Strains carrying this gene

Strain Genotype Description
KR674 imb-1(h353) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are Lethal DpyUnc.
KR676 let-630(h355) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest as Sterile adults.
KR677 let-548(h356) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in early larval development.
KR684 let-642(h363) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in mid larval development.
KR697 hDf24 dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc.
KR717 let-502(h392) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Unc-13 phenotype. Segregates Uncs and lethal DpyUncs (h392 arrests as a mid-stage larva). Pick Unc-13 animals to maintain. This strain was generated by the Genetic Toolkit project, which should be acknowledged in any publications resulting from its use: The Genetic Toolkit is funded by the NIH National Center for Research Resources (NCRR) (USA) to Ann M. Rose, David L. Baillie, and Donald L. Riddle. Report all experimental results to Ann Rose.
KR727 dpy-5(e61) let-607(h402) unc-13(e450) I; sDp2 (I;f). Unc-13 phenotype. h402 arrests as an embryo. Pick Unc-13 animals to maintain. This strain was generated by the Genetic Toolkit project, which should be acknowledged in any publications resulting from its use: The Genetic Toolkit is funded by the NIH National Center for Research Resources (NCRR) (USA) to Ann M. Rose, David L. Baillie, and Donald L. Riddle. Report all experimental results to Ann Rose.
KR730 let-526(h405) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in early/mid larval development.
KR744 let-632(h419) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in early larval development.
KR751 let-505(h426) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication arrest in embyronic development.
KR753 nars-1(h428) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the Dup are Unc. Animals which have lost the Dup are DpyUncLet and arrest in early larval development. Maintain by picking Unc.
KR763 let-507(h439) dpy-5(e61) unc-13(e450) I; sDp2 (I;f).
KR766 dpy-5(e61) let-524(h442) unc-13(e450) I; sDp2 (I;f). Unc-13 phenotype. Segregates Uncs and lethal DpyUncs. h442 arrests as an early larva. Maintain by picking Unc-13 and checking for correct segregation of progeny.
KR772 let-504(h448) dpy-5(e61) unc-13(e450) I; sDp2 (I;f).
KR773 let-624(h449) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in early larval development.
KR786 hDf25 dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc.
KR795 let-600(h468) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in late larval development.
KR823 let-649(h491) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in late larval development.
KR827 let-363(h502) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are Dpy Unc and arrest in early mid development.
KR828 let-577(h503) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in early larval development.
KR829 let-625(h506) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in early larval development.
KR833 let-578(h512) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in early larval development.
KR850 let-615(h529) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in egg/early larval development.
KR878 let-643(h500) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in late larval development.
KR881 aars-2(h505) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Unc-13 phenotype. Segregates Uncs and lethal DpyUncs (h505 arrests as a mid-stage larva). This strain was generated by the Genetic Toolkit project, which should be acknowledged in any publications resulting from its use: The Genetic Toolkit is funded by the NIH National Center for Research Resources (NCRR) (USA) to Ann M. Rose, David L. Baillie, and Donald L. Riddle. Report all experimental results to Ann Rose.
KR917 ptr-2(h345) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in egg/early larval development.
KR919 let-571(h347) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are DpyUnc and arrest in early larval development.
KR920 let-619(h348) dpy-5(e61) unc-13(e450) I; sDp2 (I;f). Animals with the duplication are Unc. Animals which have lost the duplication are Dpy Unc and arrest in early mid development.
KR926 hDf6 dpy-5(e61) unc-13(e450)/szT1 [lon-2(e678)] I; unc-3(e151)/szT1 X. This strain was generated by the Genetic Toolkit project, which should be acknowledged in any publications resulting from its use: The Genetic Toolkit is funded by the NIH National Center for Research Resources (NCRR) (USA) to Ann M. Rose, David L. Baillie, and Donald L. Riddle. Report all experimental results to Ann Rose.
MAS94 mei-1(ct46) unc-13(e1091) I; unc-119(ed3) III; abcIs3. abcIs3 [pie-1p::ebp-2::GFP + unc-119(+)]. Embryonic-lethal at 25ÂșC due to dominant gain-of-function mutation mei-1(ct46), and Uncoordinated due to unc-13 mutation. Maternal expression of EBP-2::GFP microtubule end-binding protein. EBP-2 encodes an EB1-like protein (end-binding) that, in early embryos, locates to the growing tips of microtubules. A strong fluorescent signal localizes to the centrosomes of early embryos due to a high concentration of polymerizing microtubules. mei-1(ct46)-based ectopic microtubule severing causes mitotic spindle defects in the early embryo. References: Gusnowski EM, Srayko M. J Cell Biol. 2011 Aug 8;194(3):377-86. Tegha-Dunghu J, et al. Methods Mol Biol. 2014;1136:103-16.
MT1488 lin-17(n677) unc-13(e1091) I.
MT2138 nDf29/unc-13(e1091) lin-11(n566) I.
MT2139 nDf30/unc-13(e1091) lin-11(n566) I. Heterozygotes are Vul and segregate Vul, UncVul and dead eggs. Maintain by picking Vul non-Unc.
MT2179 nDf25/unc-13(e1091) lin-11(n566) I. Heterozygotes are WT and segregate WT, UncVul and dead eggs. The UncVuls are small, kinky, paralyzed and vulvaless. Maintain by picking WT.
MT2180 nDf23/unc-13(e1091) lin-11(n566) I. Heterozygotes are WT and segregate WT, UncVul and dead eggs. UncVuls are small, kinky, paralyzed and vulvaless. Maintain by picking WT.
MT2181 nDf24/unc-13(e1091) lin-11(n566) I. Hets are WT and segregate WT, dead eggs, and VulUnc. VulUncs are small, kinky, paralyzed and vulvaless. Maintain by picking WT.
MT2936 unc-13(e51) I; nDp4 (I;V)/+. Animals heterozygous for the duplication are WT. Animals which have lost the duplication are Unc. Animals homozygous for the duplication are viable. They are small, sickly Egl worms which don't give rise to Uncs.
MT3033 unc-13(e1091) lin-35(n745) I. Unc.
MT3184 sem-4(n1378) unc-13(e51) I. Unc. Egl. Transformation of sex myoblasts into body wall muscle.
MT3198 unc-13(e1091) unc-29(e1072) I.
MT3608 unc-13(e51) ced-1(e1735) I. Unc. Abnormal cell death.
MT7929 unc-13(e51) I. Unc. See WBPaper00003781.
MT8004 unc-13(n2813) I.
NL1787 unc-13(e51) I. NL subclone of KR1787. NL subclone of KR1787. NL received strain KR1787 from Ann Rose 11/93. High copy Tc1 strain. See WBG 14(4): 16-17.
PJ1002 unc-13(e51) I; ccIs55 V. ccIs55 [unc-54::lacZ + sup-7(st5)] V. Unc.
RK1 unc-13(e323) I; jsIs1. jsIs1 [(pSB120) snb-1::GFP + rol-6(su1006)]. Roller Unc.
RM2431 unc-13(md2415)/hT1 I; +/hT1 V. Heterozygotes are WT and segregate WT, hT1 homozygotes (mid-larval lethals), md2415 homozygotes (generally L1 lethals which are almost completely paralyzed and have a coily posture with some head movement), and dead eggs. md2415 has a 2.7 kb deletion in the "unc-13R" region.
SD63 dpy-5(e61) unc-13(e51) I; gaDp1 (I;f). Animals with the duplication are WT. Animals which have lost the duplication are DpyUnc. Maintain by picking WT.
SP1540 mnDf111/unc-13(e1091) lin-11(n566) I. Heterozygotes are WT and segregate WT, dead eggs and UncVul.
SS230 unc-13(e51) I; him-5(e1490) V; nDp4 (I;V)/+. Animals with the Duplication are WT. Animals which have lost the Duplication are Unc. Throws males.