Gene Information: unc-13

Nameunc-13 View on WormBase
Species C. elegans
SequenceZK524.2
Genetic positionI:2.07 +/- 0.004 cM
Genomic positionI: 7422785..7454116

Strains carrying this gene

Strain Genotype Description
AC68 unc-29(e1072) aph-2(zu181)/unc-13(e1091) lin-11(n566) I. Heterozygotes are WT and segregate WT, Unc Egls, and dead eggs.
AG151 cdc-25.1(nr2036)/dpy-5(e61) unc-13(e450) I. Heterozygotes are WT and segregate WT, DpyUncs and adult steriles. Original deletion from Axys Pharmaceuticals.
AG165 san-1(av31) unc-13(e450) I. Unc. Reduced brood size. Larval lethal, larval arrest. Steriles. Bursts at vulva. Can be maintained as a homozygote.
AMH61 unc-13(e51) I; ddi-1(ok1468) IV. ddi-1 also known as vsm-1.
BC110 dpy-14(e188) unc-13(e51) let-85(s142)/unc-15(e73) I. Heterozygotes are WT and segregate WT, Unc and DpyUncLets. Lethal at L1. Maintain by picking WT.
BC112 dpy-14(e188) unc-13(e51) let-82(s85)/unc-15(e73) I. Heterozygotes are WT and segregate more WT, paralyzed Unc, and DpyUncLet (DpyUnc Larvae are abnormal). Maintain by picking WT.
BC115 dpy-14(e188) unc-13(e51) let-81(s88)/unc-15(e73) I. Heterozygotes are WT and segregate more WT, paralyzed Unc and DpyUncLethals. The DpyUncLets are abnormal larvae and die in early larval development. Pick WT to maintain.
BC123 dpy-14(e188) unc-13(e51) let-84(s91)/unc-15(e73) I. Heterozygotes are WT and segregate more WT, paralyzed Unc and DpyUncLet. The DpyUncs are abnormal larvae that die in late larval development. Pick WT to maintain.
BC124 dpy-14(e188) unc-13(e51) unc-37(s80)/unc-15(e73) I. Heterozygotes are WT and segregate more WT, paralyzed Unc and DpyUncLet. The DpyUncLet larvae are abnormal. Pick WT to maintain.
BC125 dpy-14(e188) unc-13(e51) let-79(s81)/unc-15(e73) I. Heterozygotes are WT and segregate more WT, paralyzed Unc and DpyUncLethal. The DpyUncs are abnormal larvae that die in early larval development. Pick WT to maintain. Note 5/92: probably has lost dpy-14.
BC148 dpy-14(e188) let-75(s101) unc-13(e51)/unc-15(e73) I. Heterozygotes are WT and segregate more WT, paralyzed Unc and DpyUncLethals. The DpyUncs are abnormal larvae that die in early larval development (L1). Pick WT to maintain. Previously called myo-1(s101).
BC149 dpy-14(e188) unc-13(e51) let-83(s97)/unc-15(e73) I. Heterozygotes are WT and segregate more WT, paralyzed Unc and DpyUncLethals. The DpyUnc are abnormal larvae which die in early larval development. Pick WT to maintain.
BC157 dpy-14(e188) unc-13(e51) let-80(s96)/unc-15(e73) I. Heterozygotes are WT and segregate more WT, paralyzed Unc and Lethal DpyUncs. Lethal early larval. Pick WT to maintain.
BC159 dpy-5(e61) unc-13(e51) I; sDp1 (I;f). Animals with the duplication are WT. Animals which have lost the duplication are DpyUnc. Segregates 2% males. The males are sterile. The duplication is homozygous lethal.
BC160 dpy-14(e188) unc-13(e51) let-87(s106)/unc-15(e73) I. Heterozygotes are WT and segregate WT, paralyzed Unc and DpyUncLethal. Lethal early larval (L1). Maintain by picking WT.
BC162 dpy-14(e188) unc-13(e51) let-88(s132)/unc-15(e73) I. Heterozygotes are WT and segregate WT, paralyzed Unc and DpyUncLethal. The DpyUncs are abnormal larvae which die in early larval development. Pick WT to maintain.
BC165 dpy-14(e188) unc-13(e51) let-89(s133)/unc-15(e73) I. Heterozygotes are WT and segregate WT, paralyzed Unc and DpyUncLethal. Lethal early larval. Maintain by picking WT.
BC184 dpy-14(e188) unc-13(e51) bli-4(s90)/unc-15(e73) I. Heterozygotes are WT and segregate WT, paralyzed Unc and DpyUncLethals. The DpyUncs are abnormal larvae which die in late larval development. Pick WT to maintain. s90 previously called let-77. See also WBPaper00003507. CGC received new stock 3/01.
BC215 dpy-14(e188) unc-13(e51) let-78(s82)/unc-15(e73) I. Heterozygotes are WT and segregate more WT, paralyzed Unc and DpyUncLethals. The DpyUncs are abnormal larvae which die in late larval development. Pick WT to maintain.
BC220 dpy-14(e188) unc-13(e51) let-90(s140)/unc-15(e73) I. Heterozygotes are WT and segregate WT, paralyzed Unc and DpyUncLethal. The DpyUncs are abnormal larvae. Pick WT to maintain.
BC244 dpy-14(e188) let-86(s141) unc-13(e51)/unc-15(e73) I. Heterozygotes are WT and segregate more WT, paralyzed Unc and DpyUncLethals. The DpyUncs are abnormal larvae which die in early larval development. Pick WT to maintain.
BC455 unc-15(e73) unc-13(e51) I. Paralysed Unc.
BS3156 unc-13(e51) gld-1(q485)/hT2 [dpy-18(h662)] I; +/hT2 [bli-4(e937)] III. Heterozygotes are wild-type and segregate WT heterozygotes, Unc (unc-13 gld-1 homozygotes), and Dpy (hT2 homozygotes; the bli-4 mutation is suppressed by dpy-18). XX Uncs have tumorous germline and are sterile; XO Uncs are cross fertile (though they don't mate due to the Unc mutation). q485 is the canonical allele of gld-1. It behaves like deletions of the locus in complementation tests and thus is genetically null. Molecularly, it is a deletion of 82 bases and fails to produce gld-1 RNA and protein.
BS585 unc-13(e51) ozDf5 I; nDp4 (I;V)/+. Strain gives WT hermaphrodites and dead eggs.
BW1053 dpy-14(e188) unc-13(e1091) I. Unc. Temperature-sensitive Dpy. Grows best at 15C.
BW538 unc-13(e1091) lin-10(e1438) I. Unc and Vul.
CB1091 unc-13(e1091) I. Unc-paralysed, kinky, small, irregular pharyngeal pumping. Suppressed by sup-5 and sup-7.
CB1747 unc-13(e309) I; sup-6(st19)/+ II; daf-1(e1146) IV. Heterozygotes are WT and segregate WT, UncDaf and Lethals. Suppressed Unc in hets. Suppressed Daf in hets. sup-6 is recessive lethal.
CB2167 dpy-5(e61) unc-13(e1091) I. Dpy. Unc.
CB2987 unc-13(e309) I; dpy-10(e128) sup-6(st19)/dpy-10(e128) II. Dominant suppressor of Unc. Dpy. sup-6 is recessive lethal. Heterozygotes are Dpy non-Unc. Pick Dpy non-Unc to maintain.
CB312 unc-13(e312) I. Slightly Unc. Suppressed by sup-5 and sup-7. Null allele?
CB376 unc-13(e376) I. Slightly Unc. Suppressed by sup-5 and sup-7. Null allele?
CB450 unc-13(e450) che-3(ky1018) I. Paralyzed Unc. This strain carries a tightly linked mutation, che-3(ky1018), that changes Q1107 of che-3 to a stop codon. Reference: Larsch, et al. (2015) Cell Reports.
CB51 unc-13(e51) unc-122(n2916) I. Unc. See WBPaper00003781 regarding the unc-122 mutation.
CGC138 unc-13(e51)/hT1 I; dpy-11(e224)/hT1 [unc-42(e270) umnIs79] V. umnIs79 [myo-2p::GFP + NeoR, I: 6284001] I. Pick wild-type GFP+ to maintain. Heterozygotes are wild-type GFP+, and segregate wild-type GFP+, DpyUnc, arrested hT1 homozygotes (GFP+), and dead eggs. Maintain by picking wild-type GFP+. Derived by insertion of myo-2p::GFP transgene into hT1 balancer in parental strain KR1037 using CRISPR/Cas9.
CGC139 unc-13(e51)/hT1 I; dpy-11(e224)/hT1 [unc-42(e270) umnIs80] V. umnIs80 [myo-2p::mKate2 + NeoR, I: 6284001] I. Pick wild-type mKate2+ to maintain. Heterozygotes are wild-type mKate2+, and segregate wild-type mKate2+, DpyUnc, arrested hT1 homozygotes (mKate2+), and dead eggs. Maintain by picking wild-type mKate2+. Derived by insertion of myo-2p::mKate transgene into hT1 balancer in parental strain KR1037 using CRISPR/Cas9.
CGC29 unc-13(e51)/hT1 [umnIs18] I; dpy-11(e224)/hT1 [unc-42(e270)] V. umnIs18 [myo-2p::GFP + NeoR, V: 1005689 (intergenic)] I. Heterozygotes are wild-type GFP+, and segregate wild-type GFP+, Dpy Unc, arrested hT1 homozygotes, and dead eggs. Maintain by picking wild-type GFP+. Derived by insertion of myo-2p::GFP transgene into hT1 balancer in parental strain KR1037 using CRISPR/Cas9.
CGC75 unc-13(e51)/hT1 [umnIs58] I; dpy-11(e224)/hT1 [unc-42(e270)] V. umnIs58 [myo-2p::mKate2 + NeoR, V: 1005689 (intergenic)] V. Pick wild-type mKate2+ to maintain. Heterozygotes are wild-type mKate2+, and segregate wild-type mKate2+, DpyUnc, arrested hT1 homozygotes (mKate2+), and dead eggs. Maintain by picking wild-type mKate2+. Derived by insertion of myo-2p::mKate2 transgene into hT1 balancer in parental strain KR1037 using CRISPR/Cas9.
DR168 unc-13(e51) daf-8(e1393) I. Temperature sensitive dauer constitutive. Unc. Semi-paralyzed. Closely linked.
DR435 dpy-5(e61) unc-13(e51) I. Dpy. Unc.
DR478 unc-13(e450) I; sup-7(st5) X. sup-7 suppresses unc-13. Movement not WT. Fertility is low. Grows between 22.5C and 24C.
DR497 unc-13(e450) I; daf-7(m62) III; sup-7(st5) X. Both unc-13 and daf-7 are suppressed by sup-7. sup-7 should be grown between 22.5C and 24C.
DR508 unc-13(e450) I; daf-4(m72) III; sup-7(st5) X. sup-7 suppress dauer formation. sup-7 should be grown between 22.5C and 24C.
EG9631 unc-13(s69) I. Aldicarb resistant. This allele is a small exonic deletion that frameshifts exon 21, thus deleting the MUN domain of both long and short isoforms of unc-13. The reference allele e51 is R471-stop, affecting only UNC-13L. Derived by 2x outcross of BC168. Reference: Rose AM & Baillie DL. Genetics. 1980 Nov;96(3):639-48.
EM598 hlh-2(bx115) unc-13(e51) I; him-5(e1490) V. Paralyzed Unc. Throws males. hlh-2(bx115) has no phenotype in this background.
EU414 unc-13(e1091) mom-4(or39)/hT2 I; +/hT2 [bli-4(e937) let-?(h661)] III. Heterozygotes are WT. Segregates Uncs which give only embryonic lethals which lack gut and make excess mesoderm (E adopts an MS-like fate). or39 is a recessive maternal-effect embryonic lethal.
EU443 unc-13(e1091) mom-4(or11)/hT2 I; +/hT2 [bli-4(e937) let-?(h661)] III. Heterozygotes are WT. Segregates Uncs which give only embryonic lethals which lack gut and make excess mesoderm (E adopts an MS-like fate). or11 is a recessive maternal-effect embryonic lethal.
EU446 unc-13(e1091) mom-4(or39)/hT2 I; +/hT2 [bli-4(e937) let-?(h661)] III. Heterozygotes are WT. Segregates Uncs which give only embryonic lethals which lack gut and make excess mesoderm (E adopts an MS-like fate). or39 is a recessive maternal-effect embryonic lethal.
EU447 unc-13(e1091) mom-4(or39)/hT2 I; +/hT2 [bli-4(e937) let-?(h661)] III; him-8(e1489) IV. Heterozygotes are WT. Segregates Uncs which give only embryonic lethals which lack gut and make excess mesoderm (E adopts an MS-like fate). or39 is a recessive maternal-effect embryonic lethal. Throws males.
EU452 mom-5(zu193) unc-13(e1091)/hT2 I; +/hT2 [bli-4(e937) let-?(h661)] III. Heterozgyotes are WT and segregate WT, Uncs which give only dead eggs, and dead eggs.